Examining the time-varying association of negative affect and covariates with craving during treatment for prescription opioid dependence with two types of mixed models.
Examining the time-varying association of negative affect and covariates with craving during treatment for prescription opioid dependence with two types of mixed models.
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用两种混合模型检验处方阿片类药物依赖治疗过程中负性情绪和协变量与渴求的时间变化关系。
DOI：
10.1016/j.addbeh.2020.106674
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发表时间：
2021-03
影响因子：
4.4
通讯作者：
Cleveland HH
中科院分区：
文献类型：
--
作者：
Jenkins GJ;Cleveland MJ;Knapp KS;Bunce SC;Cleveland HH
类阿片使用障碍是慢性的，复发是常见的。消极情绪和渴望都被认为是复发的前因，并被证明是人与人之间的变异性，以及彼此之间的关联。本研究扩展了以前的研究，通过检查阿片类药物依赖患者在12天的治疗期间，在一天内和个人水平上的负面情绪和渴望的协变。从73名参与者中收集了进入住院治疗机构后10至14天的生态瞬时评估（EMA）数据。使用多变量多水平模型和时变效应模型分析这些数据。结果表明，消极情绪和渴望之间有很强的关联。在一天之内，负面影响和渴望在下午早些时候最相关。在个人层面上，在数据收集的第一周，负面情绪和渴望之间的联系下降了。在这种最初的关联下降之后，在数据收集的第8 - 12天，负面影响和渴望越来越多地共同变化。据我们所知，这是第一项报告阿片类药物依赖住院治疗期间患者负面情绪和渴望之间相关性滞后增加的研究。研究和治疗提供者的影响进行了讨论。
Opioid use disorders are chronic and relapse is common. Both negative affect and craving have been suggested antecedents of relapse and have been shown to demonstrate within- and between-person variability, as well as association with each other. The present study extends previous research by examining the covariation of negative affect and craving both within-day and at the person-level during 12 days of treatment among opioid-dependent patients. Ecological momentary assessment (EMA) data were collected from 73 participants starting between 10 and 14 days after admission to an inpatient treatment facility. These data were analyzed using multivariate multilevel models and time-varying effect models. Results demonstrated strong association between negative affect and craving. Within-day, negative affect and craving were most associated in the early afternoon. At the person-level, association between negative affect and craving declined during the first week of data collection. Following this initial decline in association, negative affect and craving increasingly covaried during days 8 – 12 of data collection. To our knowledge, this is the first study to report a lagged increase in the association between negative affect and craving among patients during inpatient treatment for opioid dependence. Implications for research and treatment providers are discussed.
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