A Single High Dose of Methamphetamine Reduces Monoamines and Impairs Egocentric and Allocentric Learning and Memory in Adult Male Rats.
A Single High Dose of Methamphetamine Reduces Monoamines and Impairs Egocentric and Allocentric Learning and Memory in Adult Male Rats.
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DOI：
10.1007/s12640-018-9871-9
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发表时间：
2018-04
影响因子：
3.7
通讯作者：
Vorhees CV
中科院分区：
文献类型：
--
作者：
Gutierrez A;Williams MT;Vorhees CV
甲基苯丙胺（MA）改变多巴胺标记物和重度使用者的认知功能。在啮齿类动物中，有一种MA给药方案，通过间隔重复给药来诱导一致的效果。这些方案是有效的，但复杂的实验旨在解开药物对不同大脑区域的影响，以及由于治疗间隔造成的认知影响。为了简化模型，我们测试了单剂量MA是否能诱导与多次间隔给药相同的单胺和认知效应，而不影响生存。成年雄性Sprague-Dawley大鼠皮下注射40 mg/kg MA 1次，2周后开始试验。ma治疗的大鼠在辛辛那提水迷宫中表现出自我中心导航的缺陷，在莫里斯水迷宫中表现出空间导航的缺陷，在Star水迷宫中表现出选择一致的问题解决策略的缺陷。ma治疗的大鼠在新纹状体和伏隔核中持续出现多巴胺和5 -羟色胺的减少，海马中5 -羟色胺的减少程度与重复治疗模型相同。数据表明，单剂量重现了多剂量方案的神经认知和单胺效应，从而简化了ma诱导的神经毒性模型。
Methamphetamine (MA) alters dopamine markers and cognitive function in heavy users. In rodents there are MA dosing regimens that induce concordant effects using repeated administration at spaced intervals. These regimens are effective but complicate experiments designed to disentangle the effects of the drug on different brain regions in relation to their cognitive effects because of treatment spacing. In an effort to simplify the model, we tested whether a single dose of MA could induce the same monoamine and cognitive effects as multiple, spaced dosing without affecting survival. Adult male Sprague-Dawley rats were treated with 40 mg/kg MA subcutaneously once and tested starting two weeks later. MA-treated rats showed deficits in egocentric navigation in Cincinnati water maze, in spatial navigation in the Morris water maze, and in choosing a consistent problem-solving strategy in the Star water maze when given the option to show a preference. MA-treated rats had persistent dopamine and serotonin reductions in the neostriatum and nucleus accumbens, and serotonin reductions in the hippocampus of the same magnitude as in repetitive treatment models. The data demonstrate that a single dose recapitulates the neurocognitive and monoamine effects of multiple-dose regimens thereby simplifying the model of MA-induced neurotoxicity.
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影响因子：
3.7
作者：
Braun, Amanda A.;Amos-Kroohs, Robyn M.;Williams, Michael T.
通讯作者：
Williams, Michael T.
影响因子：
6
作者：
Chang, Linda;Alicata, Daniel;Volkow, Nora
通讯作者：
Volkow, Nora
DOI：
10.1016/s0163-1047(88)90338-x
发表时间：
1988-05-01
期刊：
BEHAVIORAL AND NEURAL BIOLOGY
影响因子：
--
作者：
COOK, D;KESNER, RP
通讯作者：
KESNER, RP
影响因子：
3.6
作者：
Daberkow, DP;Kesner, RP;Keefe, KA
通讯作者：
Keefe, KA
影响因子：
2.7
作者：
Braun, Amanda A.;Amos-Kroohs, Robyn M.;Gutierrez, Arnold;Lundgren, Kerstin H.;Seroogy, Kim B.;Skelton, Matthew R.;Vorhees, Charles V.;Williams, Michael T.
通讯作者：
Williams, Michael T.