The diagnosis of limbal stem cell deficiency.

The diagnosis of limbal stem cell deficiency.
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DOI:
10.1016/j.jtos.2017.11.002
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发表时间:
2018-01
期刊:
The ocular surface
影响因子:
--
通讯作者:
Deng SX
Deng SX
中科院分区:
其他
文献类型:
--
作者:
Le Q;Xu J;Deng SX

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角膜缘干细胞(LSC)维持角膜上皮的正常稳态和伤口愈合。角膜缘干细胞缺乏症 (LSCD) 是一种由 LSC 功能障碍和/或数量不足引起的病理状况。 LSCD 的诊断主要根据病史和临床体征,而这些往往不是 LSCD 所特有的。一直缺乏对 LSCD 严重程度进行分级的方法。通过应用新开发的眼部成像模式和分子方法作为诊断工具,可以建立 LSCD 分期的标准化定量标准。由于这些最新进展,针对 LSCD 不同阶段的有效患者特异性治疗可能是可行的。
Limbal stem cells (LSCs) maintain the normal homeostasis and wound healing of corneal epithelium. Limbal stem cell deficiency (LSCD) is a pathologic condition that results from the dysfunction and/or an insufficient quantity of LSCs. The diagnosis of LSCD has been made mainly based on medical history and clinical signs, which often are not specific to LSCD. Methods to stage the severity of LSCD have been lacking. With the application of newly developed ocular imaging modalities and molecular methods as diagnostic tools, standardized quantitative criteria for the staging of LSCD can be established. Because of these recent advancements, effective patient-specific therapy for different stages of LSCD may be feasible.
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