Diversity of the Swine Leukocyte Antigen Class I and II in Commercial Pig Populations.
Diversity of the Swine Leukocyte Antigen Class I and II in Commercial Pig Populations.
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DOI：
10.3389/fvets.2021.637682
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发表时间：
2021
影响因子：
3.2
通讯作者：
Suradhat S
中科院分区：
文献类型：
--
作者：
Techakriengkrai N;Nedumpun T;Golde WT;Suradhat S
在猪的遗传标记中，高度多态性的猪白细胞抗原（SLA）是一个关键的决定因素，不仅与免疫反应，而且与繁殖性能和肉质有关。本研究的目的是描述商业猪群体中SLA I类和II类的特征。在本研究中，从5家主要养猪公司的不同种猪群中随机选择了158头猪（126头后备母猪和32头公猪），占泰国猪产量的70%。结果表明，中等水平的SLA多样性保持在泰国猪种群，尽管性能导向的育种计划。高度常见的SLA I类等位基因为SLA-1*08：XX、SLA-2*02：XX和SLA-3*04：XX，组合频率分别为30.1%、18.4%和34.5%，而DRB 1 *04：XX、DQB 1 *02：XX和DQA*02：XX是常见的II类等位基因，组合频率分别为22.8%、33.3%和38.6%。单倍型Lr-32.0（SLA-1*07：XX、SLA-2*02：XX和SLA-3*04：XX）和Lr-0.23（DRB 1 *10：XX、DQB 1 *06：XX、DQA* 01：XX）是最常见的SLA I类和II类单倍型，分别为15.5%和14.6%。还观察到常见的I类和II类单倍型，其中Lr-22.15最占优势，占11.1%，其次是Lr-32.12和Lr-4.2，分别占10.8%和7.9%。据我们所知，这是在东南亚首次报道的商业猪中的SLA I和II类疾病。群体中常见SLA等位基因的信息可以为猪的遗传改良和未来的疫苗设计提供帮助。
Among swine genetic markers, the highly polymorphic swine leukocyte antigen (SLA) is one of the key determinants, associated with not only immune responses but also reproductive performance and meat quality. The objective of this study was to characterize the SLA class I and II diversities in the commercial pig populations. In this study, a total number of 158 pigs (126 gilts and 32 boars) were randomly selected from different breeding herds of five major pig-producing companies, which covered ~70% of Thai swine production. The results indicate that a moderate level of SLA diversity was maintained in the Thai swine population, despite the performance-oriented breeding scheme. The highly common SLA class I alleles were SLA-1*08:XX, SLA-2*02:XX, and SLA-3*04:XX at a combined frequency of 30.1, 18.4, and 34.5%, respectively, whereas DRB1*04:XX, DQB1*02:XX and DQA*02:XX were the common class II alleles at 22.8, 33.3, and 38.6%, respectively. The haplotype Lr-32.0 (SLA-1*07:XX, SLA-2*02:XX, and SLA-3*04:XX) and Lr-0.23 (DRB1*10:XX, DQB1*06:XX, DQA* 01:XX) was the most common SLA class I and II haplotype, at 15.5 and 14.6%, respectively. Common class I and II haplotypes were also observed, which Lr-22.15 was the most predominant at 11.1%, followed by Lr-32.12 and Lr-4.2 at 10.8 and 7.9%, respectively. To our knowledge, this is the first report of SLA class I and II diversities in the commercial pigs in Southeast Asia. The information of the common SLA allele(s) in the population could facilitate swine genetic improvement and future vaccine design.
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DOI：
10.1530/jrf.0.0820595
发表时间：
1988-03-01
期刊：
JOURNAL OF REPRODUCTION AND FERTILITY
影响因子：
--
作者：
CONLEY, AJ;JUNG, YC;FORD, SP
通讯作者：
FORD, SP
DOI：
10.1146/annurev-animal-020518-115014
发表时间：
2020-01-01
期刊：
ANNUAL REVIEW OF ANIMAL BIOSCIENCES, VOL 8, 2020
影响因子：
--
作者：
Hammer, Sabine E.;Ho, Chak-Sum;Lunney, Joan K.
通讯作者：
Lunney, Joan K.
影响因子：
3.2
作者：
Ballingall, Keith T.;Bontrop, Ronald E.;Marsh, Steven G. E.
通讯作者：
Marsh, Steven G. E.
影响因子：
2.4
作者：
GAUTSCHI, C;GAILLARD, C
通讯作者：
GAILLARD, C
影响因子：
4.6
作者：
Minh Thong Le;Choi, Hojun;Park, Chankyu
通讯作者：
Park, Chankyu