Serotonergic projections from the caudal raphe nuclei to the hypoglossal nucleus in male and female rats.
Serotonergic projections from the caudal raphe nuclei to the hypoglossal nucleus in male and female rats.
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DOI：
10.1016/j.resp.2008.11.008
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发表时间：
2009-02-28
影响因子：
2.3
通讯作者：
Behan, Mary
中科院分区：
文献类型：
--
作者：
Barker, Jessica R.;Thomas, Cathy F.;Behan, Mary
呼吸控制系统是两性二态的。在包括呼吸运动核在内的许多大脑区域，女性的血清素（5HT）水平高于男性。我们假设5HT输入到舌下核（脑干中参与上呼吸道控制的区域）可能存在性别差异。将成年Fischer 344大鼠麻醉后，向舌部注射逆行经突触神经解剖示踪剂Bartha伪狂犬病毒（PRV）。通过髓质切片进行免疫细胞化学反应，检测(i) PRV, （ii）色氨酸羟化酶（TPH； 5HT神经元的标记物），（iii） PRV与TPH结合，（iv） 5HT。在雌性大鼠中测量性激素水平，并与TPH免疫反应性相关，因为舌下5HT水平随发情周期变化。雄性和雌性大鼠的PRV神经元数量相当。雌雄大鼠中缝尾核中TPH免疫反应神经元的数量和分布相似。支配舌下运动神经元的5HT神经元亚群在雄性和雌性大鼠中也相似。除了舌下核腹外侧区外，雄性和雌性大鼠的5HT免疫反应性相似。这些数据表明，雄性和雌性大鼠舌下运动神经元5HT调节的性别差异不是TPH或5HT的性别差异的结果，而可能与神经递质释放和再摄取的差异、舌下运动神经元上5HT突触末端的位置、突触前和突触后5HT受体表达的差异，或性激素受体在舌下或尾状神经元上的分布有关。
The respiratory control system is sexually dimorphic. In many brain regions, including respiratory motor nuclei, serotonin (5HT) levels are higher in females than in males. We hypothesized that there could be sex differences in 5HT input to the hypoglossal nucleus, a region of the brainstem involved in upper airway control. Adult Fischer 344 rats were anesthetized and a retrograde transsynaptic neuroanatomical tracer, Bartha pseudorabies virus (PRV), was injected into the tongue. Sections through the medulla were reacted immunocytochemically for the presence of (i) PRV, (ii) tryptophan hydroxylase (TPH; marker of 5HT neurons), (iii) PRV combined with TPH, and (iv) 5HT. Sex hormone levels were measured in female rats and correlated with TPH immunoreactivity, as hypoglossal 5HT levels vary with the estrous cycle. The number of PRV neurons was comparable in male and female rats. The number and distribution of TPH immunoreactive neurons in the caudal raphe nuclei were similar in male and female rats. The subset of 5HT neurons that innervate hypoglossal motoneurons was also similar in male and female rats. With the exception of the ventrolateral region of the hypoglossal nucleus, 5HT immunoreactivity was similar in male and female rats. These data suggest that sex differences in 5HT modulation of hypoglossal motoneurons in male and female rats are not the result of sex differences in TPH or 5HT, but may result from differences in neurotransmitter release and reuptake, location of 5HT synaptic terminals on hypoglossal motoneurons, pre- and postsynaptic 5HT receptor expression, or the distribution of sex hormone receptors on hypoglossal or caudal raphe neurons.
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影响因子：
2.3
作者：
Behan, Mary;Wenninger, Julie M.
通讯作者：
Wenninger, Julie M.
影响因子：
2.9
作者：
Boldrini, M;Underwood, MD;Arango, V
通讯作者：
Arango, V
影响因子：
2.3
作者：
Behan, M;Zabka, AG;Mitchell, GS
通讯作者：
Mitchell, GS
影响因子：
3.8
作者：
ALDES, LD;MARCO, LA;CHRONISTER, RB
通讯作者：
CHRONISTER, RB
DOI：
10.1016/s0034-5687(97)00079-0
发表时间：
1997-11-01
期刊：
RESPIRATION PHYSIOLOGY
影响因子：
--
作者：
Bayliss, DA;Viana, F;Berger, AJ
通讯作者：
Berger, AJ