The complex portal--an encyclopaedia of macromolecular complexes.
The complex portal--an encyclopaedia of macromolecular complexes.
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DOI：
10.1093/nar/gku975
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发表时间：
2015-01
影响因子：
14.9
通讯作者：
Orchard S
中科院分区：
文献类型：
--
作者：
Meldal BH;Forner-Martinez O;Costanzo MC;Dana J;Demeter J;Dumousseau M;Dwight SS;Gaulton A;Licata L;Melidoni AN;Ricard-Blum S;Roechert B;Skyzypek MS;Tiwari M;Velankar S;Wong ED;Hermjakob H;Orchard S
完整分子相互作用数据库创建了一个新的、免费的、开源的、人工管理的资源--复合体门户网站(www.ebi.ac.uk/intein/Complex)，主要模式生物的蛋白质复合体正在通过该门户网站进行整理，并可供搜索、查看和下载。它是在与其他生物信息学服务密切合作的情况下建立的，并由来自ChEMBL、MatrixDB、PDBe、Reactome和UniProtKB的数据填充。每个条目包含有关参与的分子(包括小分子和核酸)、它们的化学计量、拓扑和结构组装的信息。复合体用其功能、性质和复合体特有的基因本体论(GO)术语进行了详细的注释。在整个资源中使用一致的命名法，并提供了系统名称、推荐名称和同义词列表。证据代码本体论的使用使我们能够指出哪些条目有直接的实验证据可用，或者复合体是否已经基于同源或同源同源推断。这些数据可以使用标准识别符进行搜索，例如UniProt、Chebi和GO ID、蛋白质、基因和复合体名称或同义词。这一参考资源将得到维护和发展，以涵盖越来越多的生物体。欢迎具有特定专业领域的团体和个人提供意见。
The IntAct molecular interaction database has created a new, free, open-source, manually curated resource, the Complex Portal (www.ebi.ac.uk/intact/complex), through which protein complexes from major model organisms are being collated and made available for search, viewing and download. It has been built in close collaboration with other bioinformatics services and populated with data from ChEMBL, MatrixDB, PDBe, Reactome and UniProtKB. Each entry contains information about the participating molecules (including small molecules and nucleic acids), their stoichiometry, topology and structural assembly. Complexes are annotated with details about their function, properties and complex-specific Gene Ontology (GO) terms. Consistent nomenclature is used throughout the resource with systematic names, recommended names and a list of synonyms all provided. The use of the Evidence Code Ontology allows us to indicate for which entries direct experimental evidence is available or if the complex has been inferred based on homology or orthology. The data are searchable using standard identifiers, such as UniProt, ChEBI and GO IDs, protein, gene and complex names or synonyms. This reference resource will be maintained and grow to encompass an increasing number of organisms. Input from groups and individuals with specific areas of expertise is welcome.
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影响因子：
14.9
作者：
Hunter S;Jones P;Mitchell A;Apweiler R;Attwood TK;Bateman A;Bernard T;Binns D;Bork P;Burge S;de Castro E;Coggill P;Corbett M;Das U;Daugherty L;Duquenne L;Finn RD;Fraser M;Gough J;Haft D;Hulo N;Kahn D;Kelly E;Letunic I;Lonsdale D;Lopez R;Madera M;Maslen J;McAnulla C;McDowall J;McMenamin C;Mi H;Mutowo-Muellenet P;Mulder N;Natale D;Orengo C;Pesseat S;Punta M;Quinn AF;Rivoire C;Sangrador-Vegas A;Selengut JD;Sigrist CJ;Scheremetjew M;Tate J;Thimmajanarthanan M;Thomas PD;Wu CH;Yeats C;Yong SY
通讯作者：
Yong SY
影响因子：
14.9
作者：
Yook K;Harris TW;Bieri T;Cabunoc A;Chan J;Chen WJ;Davis P;de la Cruz N;Duong A;Fang R;Ganesan U;Grove C;Howe K;Kadam S;Kishore R;Lee R;Li Y;Muller HM;Nakamura C;Nash B;Ozersky P;Paulini M;Raciti D;Rangarajan A;Schindelman G;Shi X;Schwarz EM;Ann Tuli M;Van Auken K;Wang D;Wang X;Williams G;Hodgkin J;Berriman M;Durbin R;Kersey P;Spieth J;Stein L;Sternberg PW
通讯作者：
Sternberg PW
影响因子：
14.9
作者：
Hastings J;de Matos P;Dekker A;Ennis M;Harsha B;Kale N;Muthukrishnan V;Owen G;Turner S;Williams M;Steinbeck C
通讯作者：
Steinbeck C
影响因子：
14.9
作者：
Federhen S
通讯作者：
Federhen S
影响因子：
14.9
作者：
Gutmanas A;Alhroub Y;Battle GM;Berrisford JM;Bochet E;Conroy MJ;Dana JM;Fernandez Montecelo MA;van Ginkel G;Gore SP;Haslam P;Hatherley R;Hendrickx PM;Hirshberg M;Lagerstedt I;Mir S;Mukhopadhyay A;Oldfield TJ;Patwardhan A;Rinaldi L;Sahni G;Sanz-García E;Sen S;Slowley RA;Velankar S;Wainwright ME;Kleywegt GJ
通讯作者：
Kleywegt GJ