Hemolytic Performance in Two Generations of the Sputnik Left Ventricular Assist Device: A Combined Numerical and Experimental Study.
Hemolytic Performance in Two Generations of the Sputnik Left Ventricular Assist Device: A Combined Numerical and Experimental Study.
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DOI：
10.3390/jfb13010007
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发表时间：
2022-01-12
影响因子：
4.8
通讯作者：
Telyshev DV
中科院分区：
文献类型：
--
作者：
Romanova AN;Pugovkin AA;Denisov MV;Ephimov IA;Gusev DV;Walter M;Groth T;Bockeria OL;Le TG;Satyukova AS;Selishchev SV;Telyshev DV
背景：目前，左心室辅助装置（lvad）是一种成功的手术治疗终末期心力衰竭患者在等待名单或心脏移植禁忌症。在俄罗斯，Sputnik 1 LVAD也被成功地引入临床实践，作为移植的桥梁和目的地治疗设备。Sputnik 2型左心室辅助器的开发旨在小型化，以减少侵入性，优化血液相容性，并提高不同体型患者的通用性。方法：通过计算流体动力学（CFD）预测和实验评估，比较Sputnik左心室辅助装置流道内的溶血水平，并研究影响其他类型血液损伤的设计因素。所研究的工作点为叶轮转速为9100 min−1，流量为5 L/min，压头为100 mm Hg。结果：CFD预测的Sputnik 1和Sputnik 2的平均溶血指数分别为0.0090%和0.0023%。实验得到的Sputnik 1和Sputnik 2的归一化溶血指数平均值分别为0.011±0.003 g/100 L和0.004±0.002 g/100 L。结论：所获得的结果表明血液相容性有明显改善，充分满足了Sputnik 2 LVAD研制的微型化目标。
Background: Currently, left ventricular assist devices (LVADs) are a successful surgical treatment for patients with end-stage heart failure on the waiting list or with contraindicated heart transplantation. In Russia, Sputnik 1 LVAD was also successfully introduced into clinical practice as a bridge-to-transplant and a destination therapy device. Development of Sputnik 2 LVAD was aimed at miniaturization to reduce invasiveness, optimize hemocompatibility, and improve versatility for patients of various sizes. Methods: We compared hemolysis level in flow path of the Sputnik LVADs and investigated design aspects influencing other types of blood damage, using predictions of computational fluid dynamics (CFD) and experimental assessment. The investigated operating point was a flow rate of 5 L/min and a pressure head of 100 mm Hg at an impeller rotational speed of 9100 min−1. Results: Mean hemolysis indices predicted with CFD were 0.0090% in the Sputnik 1 and 0.0023% in the Sputnik 2. Averaged values of normalized index of hemolysis obtained experimentally for the Sputnik 1 and the Sputnik 2 were 0.011 ± 0.003 g/100 L and 0.004 ± 0.002 g/100 L, respectively. Conclusions: Obtained results indicate obvious improvements in hemocompatibility and sufficiently satisfy the determined miniaturization aim for the Sputnik 2 LVAD development.
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影响因子：
2.2
作者：
Fraser KH;Taskin ME;Griffith BP;Wu ZJ
通讯作者：
Wu ZJ
影响因子：
0.8
作者：
Anand, M;Rajagopal, KR
通讯作者：
Rajagopal, KR
影响因子：
3.3
作者：
Carvalho, Joao L. A.;Nielsen, Jon-Fredrik;Nayak, Krishna S.
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Nayak, Krishna S.
影响因子：
2.4
作者：
Berk, Zachary B. K.;Zhang, Jiafeng;Wu, Zhongjun J.
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Wu, Zhongjun J.
影响因子：
4.2
作者：
Bourque, Kevin;Cotter, Christopher;Burke, Edward
通讯作者：
Burke, Edward