Rapid increase in marrow fat content and decrease in marrow perfusion in lumbar vertebra following bilateral oophorectomy: an MR imaging-based prospective longitudinal study.
Rapid increase in marrow fat content and decrease in marrow perfusion in lumbar vertebra following bilateral oophorectomy: an MR imaging-based prospective longitudinal study.
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DOI：
10.3348/kjr.2015.16.1.154
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发表时间：
2015-01
影响因子：
4.8
通讯作者：
Yuan J
中科院分区：
文献类型：
--
作者：
Wáng YX;Griffith JF;Deng M;Yeung DK;Yuan J
双侧卵巢切除导致骨矿物质密度（BMD）降低，BMD降低与骨髓脂肪增加和骨髓灌注减少有关。本研究的目的是调查这些变化在卵巢切除术后多久发生。6例接受子宫切除术和双侧输卵管卵巢切除术的患者进行了研究。基线时，患者平均年龄为49.5岁（范围：45 - 54岁）。术前即刻和术后3、9和21个月，采用定量CT测量第三腰椎椎体BMD，采用MR波谱分析测量骨髓脂肪分数（FF），采用动态对比增强MRI测量骨髓灌注。卵巢切除术后BMD降低、骨髓FF增加和骨髓灌注减少同步发生。术后3个月内，BMD急剧下降12.5 ± 7.2%（n = 6），FF急剧增加92.2 ± 46.3%（n = 6），最大对比增强急剧下降23.6 ± 3.9%（n = 5），增强斜率急剧下降45.4 ± 7.7%（n = 5）。在接下来的18个月内，BMD和骨髓灌注继续下降，骨髓FF继续以较慢的速度增加。Friedman检验显示这些变化的显著趋势（p <0.05）。双侧卵巢切除导致腰椎骨密度迅速下降，骨髓脂肪含量增加，骨髓血液灌注减少。
Bilateral oophorectomy leads to reduced bone mineral density (BMD), and reduced BMD is associated with increased marrow fat and reduced marrow perfusion. Purpose of this study was to investigate how soon these changes occur following surgical oophorectomy. Six patients who underwent hysterectomy and bilateral salpingo-oophorectomy were studied. At baseline, mean patient age was 49.5 years (range: 45-54 years). Third lumbar vertebral body BMD measurement using quantitative CT, marrow fat fraction (FF) using MR spectroscopy and marrow perfusion using dynamic contrast enhanced MRI were conducted immediately prior to surgery and at 3, 9, and 21 months after surgery. Reduced BMD, increased marrow FF, and reduced marrow perfusion occurred synchronously post-oophorectomy. There was a sharp decrease of 12.5 ± 7.2% in BMD (n = 6), a sharp increase of 92.2 ± 46.3% (n = 6) in FF, a sharp decrease of 23.6 ± 3.9% in maximum contrast enhancement (n = 5), and of 45.4 ± 7.7% for enhancement slope (n = 5) during the initial 3 months post surgery. BMD and marrow perfusion continued to decrease, and marrow FF continued to increase at a slower rate during the following 18 months. Friedman test showed a significant trend for these changes (p < 0.05). Bilateral oophorectomy leads to a rapid decrease in lumbar BMD, an increase in marrow fat content, and a decrease in marrow blood perfusion.
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影响因子：
2.8
作者：
KITA, K;KAWAI, K;HIROHATA, K
通讯作者：
HIROHATA, K
影响因子：
105.7
作者：
WOLMAN, RL;CLARK, P;REEVE, J
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REEVE, J
影响因子：
120.7
作者：
CANN, CE;MARTIN, MC;JAFFE, RB
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JAFFE, RB
影响因子：
3.3
作者：
Sumino, Hiroyuki;Ichikawa, Shuichi;Kurabayashi, Masahiko
通讯作者：
Kurabayashi, Masahiko
DOI：
10.1097/gme.0b013e31804c793d
发表时间：
2007-05-01
影响因子：
2.7
作者：
Gallagher, J. Christopher
通讯作者：
Gallagher, J. Christopher