Improved cognitive morning performance in healthy older adults following blue-enriched light exposure on the previous evening.
Improved cognitive morning performance in healthy older adults following blue-enriched light exposure on the previous evening.
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DOI：
10.1016/j.bbr.2018.04.021
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发表时间：
2018-08-01
影响因子：
2.7
通讯作者：
Duffy JF
中科院分区：
文献类型：
--
作者：
Scheuermaier K;Münch M;Ronda JM;Duffy JF
暴露在光线下可能会产生急性警觉和昼夜相移效应。这项研究调查了晚间暴露于富蓝多色白(BEL)与多色白光(WL)对老年人第二天早晨睡眠惯性消散的影响。10名健康的老年人(平均年龄63.3岁；6岁)参与了一项为期13天的研究，包括三个基准日，初始昼夜节律阶段评估，四天2小时晚光暴露，光暴露后昼夜节律阶段评估和三个恢复日。参与者被随机分成BEL或WL两组，每组接受四次夜间光照，光照强度相同。在第二天早上，在每次醒来后的2、12、22和32min，参与者完成90-S数字符号替代测试以评估工作记忆，并通过清醒脑电记录评估客观警觉性。比较两组觉醒脑电记录的dsst和功率密度。随着清醒时间的延长(p<；0.0001)和研究天数的延长，两个受光组的dst表现都有所改善(p<；0.0001)。虽然我们观察到了显著的一天×群体交互作用(p=0.0004)，在光照后的前两个早晨，暴露于BEL的参与者的表现明显好于WL的参与者(后特别，p<；0.05)，但没有组的主要影响。在那几天，BEL组在觉醒脑电的西格玛和贝塔范围(p<；0.05)的一些频段显示出更高的脑电活动。与多色白光相比，晚上暴露于蓝光的白光显著改善了第二天早上的dsst表现。这与清醒EEG上较高水平的客观警觉性有关，但与睡眠或昼夜节律的变化无关。
Exposure to light can have acute alerting and circadian phase-shifting effects. This study investigated the effects of evening exposure to blue-enriched polychromatic white (BEL) vs. polychromatic white light (WL) on sleep inertia dissipation the following morning in older adults. Ten healthy older adults (average age = 63.3 yrs; 6F) participated in a 13-day study comprising three baseline days, an initial circadian phase assessment, four days with 2-h evening light exposures, a post light exposure circadian phase assessment and three recovery days. Participants were randomized to either BEL or WL of the same irradiance for the four evening light exposures. On the next mornings at 2, 12, 22 and 32 minutes after each wake time, the participants completed a 90-s digit-symbol substitution test (DSST) to assess working memory, and objective alertness was assessed using a wake EEG recording. DSST and power density from the wake EEG recordings were compared between the two groups. DSST performance improved with time awake (p< 0.0001) and across study days in both light exposure groups (p< 0.0001). There was no main effect of group, although we observed a significant day × group interaction (p=0.0004), whereby participants exposed to BEL performed significantly better on the first two mornings after light exposures than participants in WL (post-hoc, p< 0.05). On those days, the BEL group showed higher EEG activity in some of the frequency bins in the sigma and beta range (p<0.05) on the wake EEG. Exposure to blue-enriched white light in the evening significantly improved DSST performance the following morning when compared to polychromatic white light. This was associated with a higher level of objective alertness on the wake EEG, but not with changes in sleep or circadian timing.
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影响因子：
25
作者：
Gooley, JJ;Lu, J;Saper, CB
通讯作者：
Saper, CB
影响因子：
4.2
作者：
Duffy, Jeanne F.;Zeitzer, Jamie M.;Czeisler, Charles A.
通讯作者：
Czeisler, Charles A.
影响因子：
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作者：
Kripke DF;Elliott JA;Youngstedt SD;Rex KM
通讯作者：
Rex KM
影响因子：
5.6
作者：
LACK, L;WRIGHT, H
通讯作者：
WRIGHT, H
影响因子：
5.5
作者：
Dijk, DJ;Duffy, JF;Czeisler, CA
通讯作者：
Czeisler, CA