Monitoring Gut Epithelium Serotonin and Melatonin Overflow Provides Spatial Mapping of Inflammation.
Monitoring Gut Epithelium Serotonin and Melatonin Overflow Provides Spatial Mapping of Inflammation.
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DOI：
10.1002/cbic.202200334
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发表时间：
2023-01-17
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影响因子：
--
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采用电化学阵列技术检测健康小鼠和化学诱导炎症性肠病（IBD）小鼠全结肠5-羟色胺（5-HT）和褪黑激素（MEL）的溢出，以了解炎症与结肠功能之间的相互作用。我们发现，5-HT溢出增加，而MEL水平降低，在发炎组织。MEL的水平在结肠内健康和发炎区域之间的界面处增加，并且可以限制炎症的扩散。了解炎症和粘膜上皮信号之间的相互作用可以提供对结肠功能的关键见解，并有助于开发治疗胃肠道疾病的有效治疗策略。血清素和褪黑激素在调节肠道运动中起关键作用，但也对肠道的炎症状态有关键影响。血清素和褪黑激素的溢出提供了结肠内发炎区域的空间映射。这一发现为炎症性肠病的跟踪和治疗管理提供了新的见解。
Electrochemical array was used to measure the overflow of serotonin (5-HT) and melatonin (MEL) from the entire colon of healthy mice and mice with chemical-induced inflammatory bowel disease (IBD), to understand the interplay between inflammation and colonic function. We show that 5-HT overflow is increased, whilst MEL levels are reduced, in inflamed tissues. The levels of MEL are increased at the interface between healthy and inflamed regions within the colon and may limit the spread of inflammation. Understanding the interplay between inflammation and mucosal epithelial signaling can provide key insight into colonic function and aid the development of effective therapeutic strategies to treat gastrointestinal diseases. Serotonin and melatonin play critical roles in regulating gut motility, but also have a key influence on the inflammatory status of the gut. The overflow of serotonin and melatonin provided spatial mapping of inflamed regions within the colon. This finding provides new insight into the tracking and therapeutic management of inflammatory bowel disorders.
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影响因子：
3.1
作者：
Gaudio, E;Taddei, G;Caprilli, R
通讯作者：
Caprilli, R
影响因子：
7.4
作者：
Patel, Nirav;Fagan-Murphy, Aidan;Patel, Bhavik Anil
通讯作者：
Patel, Bhavik Anil
影响因子：
10.3
作者：
PENTNEY, PT;BUBENIK, GA
通讯作者：
BUBENIK, GA
DOI：
10.1152/ajpgi.00090.2004
发表时间：
2004-11-01
影响因子：
4.5
作者：
O'Hara, JR;Ho, WN;Sharkey, KA
通讯作者：
Sharkey, KA
影响因子：
4.2
作者：
Patel, Bhavik Anil
通讯作者：
Patel, Bhavik Anil