Disruption of orbitofrontal cortex laterality in offspring from multiplex alcohol dependence families.
Disruption of orbitofrontal cortex laterality in offspring from multiplex alcohol dependence families.
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DOI：
10.1016/j.biopsych.2008.09.001
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发表时间：
2009-01-15
影响因子：
10.6
通讯作者：
Keshavan, Matcheri S.
中科院分区：
文献类型：
--
作者：
Hill, Shirley Y.;Wang, Shuhui;Kostelnik, Bryan;Carter, Howard;Holmes, Brian;McDermott, Michael;Zezza, Nicholas;Stiffier, Scott;Keshavan, Matcheri S.
酒精依赖（AD）的易感性增加可能与大脑回路的结构差异有关，这些差异会影响奖励的显着性和/或改变信息处理的效率。眶额皮质（OFC）在调节情绪处理中的作用及其与冲动行为的关联越来越受到人们的认可。使用磁共振成像测量来自多重 AD 家庭或对照家庭的 107 个高风险和低风险后代（平均年龄 17.6 ± 4.69 岁）的 OFC。包括分段值在内的感兴趣区域测量值是由可靠的评估者使用 BRAINS2 软件获得的。统计分析根据颅内容积、年龄、社会经济地位（SES）、智商和惯用手进行调整。进行多维人格问卷（MPQ）以确定对照的量表分数。对血清素转运蛋白（5-HTT）基因和脑源性神经营养因子（BDNF）基因进行基因分型。与对照受试者相比，AD 家族的多重高风险后代表现出右/左 OFC 体积减少。右半球较小的体积与 5-HTT 和 BDNF 基因的变异显着相关。白质 (WM) 比率与 MPQ 控制量表得分呈正相关，表明 OFC WM 降低与冲动性增强相关。 AD 多重家族的后代通过表现出 OFC 体积偏侧性的破坏而表现出遗传易感性，这与更大的冲动性（较低的控制量表得分）有关。 OFC 侧向性的这种破坏与神经元生长相关基因的变异有关。
Increased susceptibility for developing alcohol dependence (AD) might be related to structural differences in brain circuits that influence the salience of rewards and/or modify the efficiency of information processing. The role of the orbitofrontal cortex (OFC) in regulating emotional processing is increasingly being recognized along with its association with impulsive behavior. Magnetic resonance imaging was used to measure the OFC in 107 high- and low-risk offspring (mean age 17.6 ± 4.69 years) from either multiplex AD families or control families. Region of interest measures including segmented values were obtained by reliable raters using BRAINS2 software. Statistical analyses were adjusted for intracranial volume, age, socioeconomic status (SES), IQ, and handedness. The Multidimensional Personality Questionnaire (MPQ) was administered to determine scale scores for Control. Genotyping was performed for the serotonin transporter (5-HTT) gene and the brain-derived neurotrophic factor (BDNF) gene. High-risk offspring from multiplex for AD families showed decreased right/left OFC volumes in comparison with control subjects. Smaller volume in the right hemisphere was significantly associated with variation in the 5-HTT and BDNF genes. White matter (WM) ratios showed a positive correlation with MPQ Control scale scores, indicating that reduced OFC WM is related to greater impulsivity. Offspring from multiplex families for AD manifest genetic susceptibility by exhibiting disruption in the laterality of the OFC volume that is related to greater impulsivity (lower Control scale scores). This disruption in OFC laterality is related to variation in genes associated with neuronal growth.
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DOI：
10.1073/pnas.0402680101
发表时间：
2004-05-25
影响因子：
11.1
作者：
Gogtay, N;Giedd, JN;Thompson, PM
通讯作者：
Thompson, PM
DOI：
10.15288/jsa.1999.60.7
发表时间：
1999-01-01
期刊：
JOURNAL OF STUDIES ON ALCOHOL
影响因子：
--
作者：
Hill, SY;Yuan, HX
通讯作者：
Yuan, HX
DOI：
10.1097/00004583-199907000-00019
发表时间：
1999-07-01
影响因子：
13.3
作者：
Hill, SY;Locke, J;Connolly, J
通讯作者：
Connolly, J
影响因子：
10.6
作者：
Hill, SY;Shen, S;Connolly, J
通讯作者：
Connolly, J
DOI：
10.1196/annals.1308.029
发表时间：
2004-01-01
期刊：
ADOLESCENT BRAIN DEVELOPMENT: VULNERABILITIES AND OPPORTUNITIES
影响因子：
--
作者：
Hill, SY
通讯作者：
Hill, SY