Pharyngeal Pressure and Timing During Bolus Transit.
Pharyngeal Pressure and Timing During Bolus Transit.
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DOI：
10.1007/s00455-016-9743-5
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发表时间：
2017-03
期刊：
影响因子：
2.6
通讯作者：
McCulloch TM
中科院分区：
文献类型：
--
作者：
Walczak CC;Jones CA;McCulloch TM
测定食管上括约肌（UES）和食道的肠内压（IBP）提供了令人信服的证据，表明IBP可以预测吞咽功能障碍。研究主要关注下咽下部区域，但没有调查整个咽部的IBP测量能告诉我们什么。我们提出了一项研究来描述运动丸内和周围的压力，通过咽和进入UES。10名健康受试者同时吞入10个10ml薄液钡丸进行HRM和显像透视检查。通过视频透视术跟踪了三个围绕丸运动的事件，另外两个事件是通过压力测量发现的。当药丸通过咽部时，在药丸头部及其下方会产生低压。当药丸通过咽部时，压力适度增加，最后在药丸尾部观察到高压，随后产生更大的压力。HRM允许在咽数据收集中获得更高的分辨率，并且在本研究中，有助于识别下咽和UES周围的半独特特征，这些特征与该区域的复杂解剖结构和UES从主动闭合到放松打开的过渡相一致。未来，针对老年和患病人群的更多研究可能会更好地了解疾病的病因和治疗方案。
Determining intrabolus pressure (IBP) at the upper esophageal sphincter (UES) and in the esophagus has given compelling evidence that IBP can be a predictor for swallowing dysfunction. Studies have looked most superiorly at the low hypopharynx region but there has been no inquiry into what IBP measures throughout the entire pharynx can tell us. We present a study to describe the pressures within and surrounding the moving bolus throughout the pharynx and into the UES. Simultaneous HRM and videofluoroscopy were performed in 10 healthy subjects swallowing ten 10 mL thin-liquid barium boluses. Three events surrounding bolus movement were tracked via videofluoroscopy, two additional events were found using manometric measures. As the bolus passes through the pharynx, low pressure is created at and below the head of the bolus. A modest pressure increase is seen as the bolus passes through the pharynx and finally, high pressure is observed at the bolus tail, followed by an even larger pressure generation of a clearance event. HRM allows for greater resolution in data collection in the pharynx and in this study, aided in identifying semi unique characteristics around the hypopharynx and the UES which are consistent with the complex anatomy of the regions and the transition of the UES from active closure to relaxed opening. In the future, additional studies designed to look at aged and diseased populations may lead to better understanding of disease etiology, and treatment options.
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影响因子：
9.8
作者：
Kwiatek, Monika A.;Mirza, Faiz;Kahrilas, Peter J.;Pandolfino, John E.
通讯作者：
Pandolfino, John E.
DOI：
10.1177/000348941011900602
发表时间：
2010-06
期刊：
The Annals of otology, rhinology, and laryngology
影响因子：
--
作者：
McCulloch TM;Hoffman MR;Ciucci MR
通讯作者：
Ciucci MR
影响因子：
--
作者：
REN, JL;MASSEY, BT;ARNDORFER, RC
通讯作者：
ARNDORFER, RC
影响因子：
29.4
作者：
COOK, IJ;DENT, J;COLLINS, SM
通讯作者：
COLLINS, SM
影响因子：
3.5
作者：
Bogte, A.;Bredenoord, A. J.;Smout, A. J. P. M.
通讯作者：
Smout, A. J. P. M.