Long-term trend of thyroid cancer risk among Japanese atomic-bomb survivors: 60 years after exposure.
Long-term trend of thyroid cancer risk among Japanese atomic-bomb survivors: 60 years after exposure.
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DOI：
10.1002/ijc.27749
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发表时间：
2013-03-01
影响因子：
6.4
通讯作者：
Mabuchi, Kiyohiko
中科院分区：
文献类型：
--
作者：
Furukawa, Kyoji;Preston, Dale;Funamoto, Sachiyo;Yonehara, Shuji;Ito, Masahiro;Tokuoka, Shoji;Sugiyama, Hiromi;Soda, Midori;Ozasa, Kotaro;Mabuchi, Kiyohiko
儿童期和青少年期电离辐射暴露后甲状腺癌风险是公众关注的话题。为了描述辐射诱发甲状腺癌风险的长期时间趋势和暴露年龄变化，我们分析了1958年至2005年期间日本原子弹幸存者寿命研究队列中105，401名成员的甲状腺癌发病率数据。在随访期间，371例甲状腺癌病例（不包括直径<10 mm的微小癌）被确定为合格受试者中的第一原发病例。使用线性剂量-反应模型，在10岁急性照射后，60岁时1戈伊辐射照射下甲状腺癌的超额相对风险估计为1.28（95%置信区间：0.59-2.70）。风险随着暴露年龄的增加而急剧下降，几乎没有证据表明20岁以后暴露的人甲状腺癌发病率增加。据估计，在20岁以前受辐射的人中，约36%的甲状腺癌病例可归因于辐射照射。虽然超额风险的幅度随着达到的年龄或自接触以来的时间的增加而降低，但与儿童期接触有关的超额甲状腺癌风险在接触后持续超过50年
Thyroid cancer risk following exposure to ionizing radiation in childhood and adolescence is a topic of public concern. To characterize the long-term temporal trend and age-at-exposure variation in the radiation-induced risk of thyroid cancer, we analyzed thyroid cancer incidence data for the period from 1958 through 2005 among 105,401 members of the Life Span Study cohort of Japanese atomic-bomb survivors. During the follow-up period, 371 thyroid cancer cases (excluding those with microcarcinoma with a diameter <10 mm) were identified as a first primary among the eligible subjects. Using a linear dose–response model, the excess relative risk of thyroid cancer at 1 Gy of radiation exposure was estimated as 1.28 (95% confidence interval: 0.59–2.70) at age 60 after acute exposure at age 10. The risk decreased sharply with increasing age-at-exposure and there was little evidence of increased thyroid cancer rates for those exposed after age 20. About 36% of the thyroid cancer cases among those exposed before age 20 were estimated to be attributable to radiation exposure. While the magnitude of the excess risk has decreased with increasing attained age or time since exposure, the excess thyroid cancer risk associated with childhood exposure has persisted for >50 years after exposure
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影响因子：
3.4
作者：
Yamada, M;Wong, FL;Suzuki, G
通讯作者：
Suzuki, G
影响因子：
6.4
作者：
Dickman, PW;Holm, LE;Hall, P
通讯作者：
Hall, P
影响因子：
5.8
作者：
Sadetzki, Siegal;Chetrit, Angela;Novikov, Ilya
通讯作者：
Novikov, Ilya
影响因子：
2.2
作者：
SHORE, RE;WOODARD, ED;HEMPELMANN, LH
通讯作者：
HEMPELMANN, LH
影响因子：
8.8
作者：
Zablotska, L. B.;Ron, E.;Masyakin, V. B.
通讯作者：
Masyakin, V. B.