Spinal pathways mediating phrenic activation during high frequency spinal cord stimulation.
Spinal pathways mediating phrenic activation during high frequency spinal cord stimulation.
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DOI：
10.1016/j.resp.2012.12.003
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发表时间：
2013-03-01
影响因子：
2.3
通讯作者：
Kowalski, Krzysztof E.
中科院分区：
文献类型：
--
作者：
DiMarco, Anthony F.;Kowalski, Krzysztof E.
高频脊髓刺激（HF-SCS）是一种通过刺激脊髓通路激活吸气肌导致膈运动神经元激活的方法。然而，介导这种反应的具体途径尚不清楚。本研究的目的是评估上颈段（C1-C4）前膈中间神经元（UCI）的潜在作用，并定位HF-SCS过程中胸段脊髓介导膈运动神经元激活的通路。在7只麻醉的脊髓（C1节段）犬中，在T2节段应用HF-SCS。在C4和C8水平连续脊髓切片之前和之后监测膈肌肌电图、吸入量和气道压力生成。C4节段和C8背柱的切片结果无显著变化。然而，侧索部分（C8水平）导致每个参数的显着减少。我们的结论是，在上胸椎HF-SCS，膈运动神经元池激活通过脊髓通路位于外侧索，但UCI不参与。
High frequency spinal cord stimulation (HF-SCS) is a method of inspiratory muscle activation resulting in phrenic motoneuron activation via stimulation of spinal cord pathways. The specific pathways mediating this response, however, are unknown. The aim of this study was to assess the potential role of upper cervical (C1–C4) pre-phrenic interneurons (UCI) and localize the pathways in the thoracic spinal cord mediating activation of phrenic motoneurons during HF-SCS. In 7 anesthetized, spinalized (C1 level) dogs, HF-SCS was applied at the T2 level. Diaphragm EMG, inspired volume and airway pressure generation were monitored before and following sequential spinal cord sections at the C4 and C8 levels. Section at the C4 level and dorsal columns at C8 resulted in no significant changes. However, lateral funiculi section (C8 level) resulted in significant reductions in each parameter. We conclude that during upper thoracic HF-SCS, the phrenic motoneuron pools are activated via spinal pathways located in the lateral funiculus but UCI are not involved.
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影响因子：
2.3
作者：
Lee KZ;Fuller DD
通讯作者：
Fuller DD
影响因子：
3.3
作者：
Lois, James H.;Rice, Cory D.;Yates, Bill J.
通讯作者：
Yates, Bill J.
影响因子：
2.5
作者：
HENNEMAN, E;SOMJEN, G;CARPENTER, DO
通讯作者：
CARPENTER, DO
影响因子：
3.3
作者：
Hayashi, F;Hinrichsen, CFL;McCrimmon, DR
通讯作者：
McCrimmon, DR
成年大鼠正常和病变的脊髓中的宫颈预性中间神经元。
影响因子：
2.5
作者：
Lane, Michael A.;White, Todd E.;Coutts, Marcella A.;Jones, Alex L.;Sandhu, Milapjit S.;Bloom, David C.;Bolser, Donald C.;Yates, Bill J.;Fuller, David D.;Reier, Paul J.
通讯作者：
Reier, Paul J.