Higher-order brain regions show shifts in structural covariance in adolescent marmosets.
Higher-order brain regions show shifts in structural covariance in adolescent marmosets.
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DOI：
10.1093/cercor/bhab470
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发表时间：
2022-09-04
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影响因子：
--
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研究青春期大脑区域的形态变化已经取得了实质性的进展，但对它们之间关系中网络层面的变化却知之甚少。在这里，我们比较了在青春期早期和成年期的135个猕猴大脑区域的形态测量体积的相关性所构建的协方差网络。前额叶(PFC)和颞叶的结构协方差网络的拓扑结构发生了实质性的变化。PFC地区在结构上变得更加分化和隔离在自己的本地网络中，假设这是为了反映成熟后专业化程度的提高。相比之下，时间区域显示出半球间协方差的增加，这可能是建立分布式网络的基础。结构协方差和成熟协方差存在区域选择性耦合，其中跨通道关联区的耦合相对较弱。后者可能是成年后继续成熟的结果，但也有环境因素，例如家庭规模，影响大脑形态。推进我们对高级脑区形态关系如何在青春期成熟的理解，加深了我们对发育中大脑的组织原理的了解。
Substantial progress has been made studying morphological changes in brain regions during adolescence, but less is known of network-level changes in their relationship. Here, we compare covariance networks constructed from the correlation of morphometric volumes across 135 brain regions of marmoset monkeys in early adolescence and adulthood. Substantial shifts are identified in the topology of structural covariance networks in the prefrontal cortex (PFC) and temporal lobe. PFC regions become more structurally differentiated and segregated within their own local network, hypothesized to reflect increased specialization after maturation. In contrast, temporal regions show increased inter-hemispheric covariances that may underlie the establishment of distributed networks. Regionally selective coupling of structural and maturational covariance is revealed, with relatively weak coupling in transmodal association areas. The latter may be a consequence of continued maturation within adulthood, but also environmental factors, for example, family size, affecting brain morphology. Advancing our understanding of how morphological relationships within higher-order brain areas mature in adolescence deepens our knowledge of the developing brain’s organizing principles.
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影响因子：
82.9
作者：
Kaiser T;Feng G
通讯作者：
Feng G
DOI：
10.1073/pnas.0402680101
发表时间：
2004-05-25
影响因子：
11.1
作者：
Gogtay, N;Giedd, JN;Thompson, PM
通讯作者：
Thompson, PM
影响因子：
34.7
作者：
Alexander-Bloch, Aaron;Giedd, Jay N.;Bullmore, Edward T.
通讯作者：
Bullmore, Edward T.
DOI：
10.1523/jneurosci.3554-12.2013
发表时间：
2013-02-13
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Alexander-Bloch A;Raznahan A;Bullmore E;Giedd J
通讯作者：
Giedd J
DOI：
10.1073/pnas.1608282113
发表时间：
2016-11-01
影响因子：
11.1
作者：
Margulies, Daniel S.;Ghosh, Satrajit S.;Smallwood, Jonathan
通讯作者：
Smallwood, Jonathan