Cognitive and Emotional Modulation of Brain Default Operation
Cognitive and Emotional Modulation of Brain Default Operation
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大脑默认操作的认知和情绪调节
DOI：
--
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发表时间：
2009
影响因子：
3.2
通讯作者：
A. Gjedde
中科院分区：
文献类型：
--
作者：
K. Pallesen;E. Brattico;C. Bailey;A. Korvenoja;A. Gjedde
目标导向的行为会降低大脑区域的活动，这些区域包括内侧额叶皮层、内侧和外侧顶叶皮层、边缘系统和边缘系统，通常被称为“默认网络”。这些活动减少被认为反映了当头脑处于休息状态时正在进行的过程的中断。在此之前，这些过程的性质是通过不同的认知任务参数来探索的，但是情感过程的存在，虽然经常假设，却很少调查。采用听觉工作记忆（auditory working memory，WM）任务，通过fMRI研究了认知负荷和情绪刺激内涵的系统变化对默认网络中任务相关性降低的影响。WM任务的表现，相比被动倾听，降低了活动的内侧和外侧，前额叶，顶叶，颞叶和边缘区。在这些区域的一个子集中，下降的幅度取决于记忆负荷;认知负荷越大，观察到的下降幅度越大。此外，在右侧杏仁核和左侧楔前叶，以前与处理不愉快的不和谐的音乐声音，有一个实验条件和刺激类型之间的相互作用。目前的结果与先前报道的任务难度对任务相关脑激活减少的影响一致。结果还表明，与任务相关的降低可能会进一步受到情绪刺激内涵的调节。
Goal-directed behavior lowers activity in brain areas that include the medial frontal cortex, the medial and lateral parietal cortex, and limbic and paralimbic brain regions, commonly referred to as the “default network.” These activity decreases are believed to reflect the interruption of processes that are ongoing when the mind is in a restful state. Previously, the nature of these processes was probed by varying cognitive task parameters, but the presence of emotional processes, while often assumed, was little investigated. With fMRI, we studied the effect of systematic variations of both cognitive load and emotional stimulus connotation on task-related decreases in the default network by employing an auditory working memory (WM) task with musical sounds. The performance of the WM task, compared to passive listening, lowered the activity in medial and lateral, prefrontal, parietal, temporal, and limbic regions. In a subset of these regions, the magnitude of decrease depended on the memory load; the greater the cognitive load, the larger the magnitude of the observed decrease. Furthermore, in the right amygdala and the left precuneus, areas previously associated with processing of unpleasant dissonant musical sounds, there was an interaction between the experimental condition and the stimulus type. The current results are consistent with the previously reported effect of task difficulty on task-related brain activation decreases. The results also indicate that task-related decreases may be further modulated by the emotional stimulus connotation.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
4.5
作者：
Bhojraj, Tejas S.;Prasad, Konasale M.;Eack, Shaun M.;Francis, Alan N.;Montrose, Debra M.;Keshavan, Matcheri S.
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Keshavan, Matcheri S.
影响因子：
3.7
作者：
Bechara, A;Tranel, D;Damasio, AR
通讯作者：
Damasio, AR
DOI：
10.1073/pnas.98.2.683
发表时间：
2001-01-16
影响因子：
11.1
作者：
Simpson, JR;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
3.7
作者：
RAICHLE, ME;FIEZ, JA;PETERSEN, SE
通讯作者：
PETERSEN, SE