Effects of transcranial focused ultrasound on human primary motor cortex using 7T fMRI: a pilot study.
Effects of transcranial focused ultrasound on human primary motor cortex using 7T fMRI: a pilot study.
复制标题
DOI：
10.1186/s12868-018-0456-6
复制
发表时间：
2018-09-14
期刊：
影响因子：
2.4
通讯作者：
Legon W
中科院分区：
文献类型：
--
作者：
Ai L;Bansal P;Mueller JK;Legon W
经颅聚焦超声（tFUS）是一种新的非侵入性神经调节技术，它利用机械能以高空间精度调节神经元的兴奋性。tFUS已被证明能够调节空间受限的人类EEG大脑活动，在这里，我们使用7 T MRI来扩展这些发现。我们测试的影响tFUS对7 T BOLD功能磁共振成像信号从个人的手指表示在人类初级运动皮层（M1）和连接的皮层运动区域。参与者（N = 5）在7 T MRI扫描仪中用拇指、食指和中指执行提示手指敲击任务，以在tFUS或假神经调节拇指表示期间为单个M1手指表示产生BOLD信号。结果表明，与假手术相比，tFUS条件下M1拇指代表的激活体积在统计学上显著增加。BOLD百分比变化没有差异，这种影响是空间局限的，因为食指和中指M1指代表没有显示出类似的显着变化，无论是百分比变化或激活体积。在tFUS至M1期间，在辅助运动区或背侧运动前皮质中未观察到任何影响。单元件tFUS可与不会引起显著伪影的高场MRI配对。tFUS增加了目标手指表示的激活体积，该目标手指表示在空间上被限制在M1内，但不延伸到功能上连接的运动区域。试用注册ClinicalTrials.gov NCT 03634631 08/14/18
Transcranial focused ultrasound (tFUS) is a new non-invasive neuromodulation technique that uses mechanical energy to modulate neuronal excitability with high spatial precision. tFUS has been shown to be capable of modulating EEG brain activity in humans that is spatially restricted, and here, we use 7T MRI to extend these findings. We test the effect of tFUS on 7T BOLD fMRI signals from individual finger representations in the human primary motor cortex (M1) and connected cortical motor regions. Participants (N = 5) performed a cued finger tapping task in a 7T MRI scanner with their thumb, index, and middle fingers to produce a BOLD signal for individual M1 finger representations during either tFUS or sham neuromodulation to the thumb representation. Results demonstrated a statistically significant increase in activation volume of the M1 thumb representation for the tFUS condition as compared to sham. No differences in percent BOLD changes were found. This effect was spatially confined as the index and middle finger M1 finger representations did not show similar significant changes in either percent change or activation volume. No effects were seen during tFUS to M1 in the supplementary motor area or the dorsal premotor cortex. Single element tFUS can be paired with high field MRI that does not induce significant artifact. tFUS increases activation volumes of the targeted finger representation that is spatially restricted within M1 but does not extend to functionally connected motor regions. Trial registration ClinicalTrials.gov NCT03634631 08/14/18
登录
查看更多内容
影响因子：
2.4
作者：
Lee W;Chung YA;Jung Y;Song IU;Yoo SS
通讯作者：
Yoo SS
影响因子：
13.9
作者：
Buzsáki G;Wang XJ
通讯作者：
Wang XJ
影响因子：
16.2
作者：
Guo, Hongsun;Hamilton, Mark, II;Lim, Hubert H.
通讯作者：
Lim, Hubert H.
影响因子：
9.2
作者：
Nir, Yuval;Fisch, Lior;Malach, Rafael
通讯作者：
Malach, Rafael
影响因子：
4.6
作者：
Lee W;Kim HC;Jung Y;Chung YA;Song IU;Lee JH;Yoo SS
通讯作者：
Yoo SS