Adiposity measures predict olfactory processing speed in older adult carriers of the apolipoprotein E ε4 allele.
Adiposity measures predict olfactory processing speed in older adult carriers of the apolipoprotein E ε4 allele.
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DOI：
10.1016/j.clinph.2011.09.001
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发表时间：
2012-05
期刊：
影响因子：
--
通讯作者：
Murphy C
中科院分区：
文献类型：
--
作者：
Zamora R;Bartholow J;Green E;Morgan CD;Murphy C
目前的研究调查了肥胖与 P3 潜伏期之间的关系。两个年龄组（18-25 岁和 65 岁以上）的 51 名成年人参加了活动。当参与者专注于电脑屏幕时，气味刺激通过嗅觉计传递。每次刺激后，屏幕上都会显示四种气味识别选项。参与者尝试通过按下按钮进行识别。记录嗅觉事件相关电位（OERP）。 BMI和腰围作为肥胖指标进行测量。在包含所有参与者的双变量分析中，观察到 P3 潜伏期与 BMI 和腰围呈正相关，表明随着肥胖的增加，潜伏期也会增加。当单独检查每个年龄组时，对于老年人来说，肥胖测量值和潜伏期之间的相关性仍然具有统计学意义。此外，还检查了 ApoE ε4 等位基因状态。老年 ε4 携带者的潜伏期与肥胖程度仍呈正相关；但在非运营商中则不然。这项研究表明，肥胖可预测老年人的嗅觉处理速度，特别是 ε4 携带者。结果表明，嗅觉处理速度可能是检测和跟踪肥胖对 AD 遗传风险人群大脑完整性和认知功能影响的有用指标。
The current study investigated the relationship between adiposity and P3 latency. Fifty-one adults in two age groups (18-25 and 65+) participated. Odor stimuli were delivered via olfactometer as participants focused on a computer screen. Each stimulus was followed by presentation on the screen of four odor identification choices. Participants attempted identification by button press. Olfactory event-related potentials (OERPs) were recorded. BMI and waist circumference were measured as indicators of adiposity. In bivarate analyses with all participants included, positive correlations for P3 latency with both BMI and waist circumference were observed, indicating that as adiposity increased latencies also increased. When each age group was separately examined, correlations between adiposity measures and latency remained statistically significant for older adults. Furthermore, ApoE ε4 allele status was examined. Latencies remained positively correlated with adiposity in older adult ε4 carriers; but not in non-carriers. This study indicates that adiposity predicts olfactory processing speed in older adults, specifically in ε4 carriers. The results suggest that olfactory processing speed may be a useful measure for detecting and following the effects of adiposity on brain integrity and cognitive function in those at genetic risk for AD.
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影响因子：
2.9
作者：
Green E;Jacobson A;Haase L;Murphy C
通讯作者：
Murphy C
影响因子：
11
作者：
Juottonen, K;Lehtovirta, M;Soininen, H
通讯作者：
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影响因子：
3
作者：
Lorig, TS;Matia, DC;Bryant, DN
通讯作者：
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影响因子：
4.2
作者：
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通讯作者：
KUHL, D
影响因子：
17.3
作者：
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通讯作者：
Comings, DE