Recent advancements in stem cell and gene therapies for neurological disorders and intractable epilepsy.
Recent advancements in stem cell and gene therapies for neurological disorders and intractable epilepsy.
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DOI：
10.1016/j.neuropharm.2010.01.019
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发表时间：
2010-05
影响因子：
4.7
通讯作者：
Ribeiro, Efrain
中科院分区：
文献类型：
--
作者：
Naegele, Janice R.;Maisano, Xu;Yang, Jia;Royston, Sara;Ribeiro, Efrain
关键词：
干细胞疗法在治疗神经疾病方面的潜在应用是巨大的。许多实验室都专注于干细胞治疗中枢神经系统疾病，包括脊髓损伤、肌萎缩侧索硬化症、帕金森病、亨廷顿病、多发性硬化症、中风、创伤性脑损伤和癫痫。在接受神经治疗测试的众多干细胞类型中，最常见的是胎儿和成人脑干细胞、胚胎干细胞、诱导多能干细胞和间充质干细胞。一个扩展的分子探针工具箱现在可以用来分析移植前后的神经干细胞命运。与此同时，正在制定方案来指导干细胞来源的神经前体细胞的命运，并筛选干细胞的致瘤性和非整倍体。该领域的快速进展表明，治疗神经疾病的新型干细胞和基因疗法正在酝酿之中。
The potential applications of stem cell therapies for treating neurological disorders are enormous. Many laboratories are focusing on stem cell treatments for CNS diseases, including spinal cord injury, Amyotrophic lateral sclerosis, Parkinson's disease, Huntington's disease, multiple sclerosis, stroke, traumatic brain injury, and epilepsy. Among the many stem cell types under testing for neurological treatments, the most common are fetal and adult brain stem cells, embryonic stem cells, induced pluripotent stem cells, and mesenchymal stem cells. An expanding toolbox of molecular probes is now available to allow analyses of neural stem cell fates prior to and after transplantation. Concomitantly, protocols are being developed to direct the fates of stem cell derived neural progenitors, and also to screen stem cells for tumorigenicity and aneuploidy. The rapid progress in the field suggests that novel stem cell and gene therapies for neurological disorders are in the pipeline.
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影响因子：
3
作者：
Bjornæs, H;Stabell, K;Loyning, Y
通讯作者：
Loyning, Y
DOI：
10.1073/pnas.0808488105
发表时间：
2008-10-28
影响因子：
11.1
作者：
Aubry, Laetitia;Bugi, Aurore;Perrier, Anselme L.
通讯作者：
Perrier, Anselme L.
DOI：
10.1073/pnas.85.23.9327
发表时间：
1988-12-01
影响因子：
11.1
作者：
BUZSAKI, G;PONOMAREFF, G;GAGE, FH
通讯作者：
GAGE, FH
影响因子：
4.4
作者：
Bacigaluppi, Marco;Pluchino, Stefano;Hermann, Dirk M.
通讯作者：
Hermann, Dirk M.
影响因子：
3.8
作者：
Alvarez-Buylla, A;Seri, B;Doetsch, F
通讯作者：
Doetsch, F