Ambient air pollution and term birth weight in Texas from 1998 to 2004.
Ambient air pollution and term birth weight in Texas from 1998 to 2004.
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从1998年到2004年，得克萨斯州的环境空气污染和期限出生体重。
DOI：
10.1080/10962247.2012.707632
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发表时间：
2012-11
期刊：
影响因子：
--
通讯作者：
Bell ML
中科院分区：
文献类型：
--
作者：
Geer LA;Weedon J;Bell ML
之前的研究已经探索了空气污染水平与出生体重降低等不良生育结果之间的关系。现有的文献表明两者之间存在关联，尽管各研究的结果并不一致。还需要进一步的研究来证实这种影响，调查暴露的重要窗口，并区分哪些污染物会造成危害。我们评估了1998至2004年间德克萨斯州1,548,904名新生儿的环境污染物浓度与足月出生体重之间的关系。产前暴露于空气污染物的分配是基于分娩时居住的母亲所在的县。检查的污染物包括空气动力学直径为≤10和≤2.5μm的颗粒物(PM10和PM2.5)、二氧化硫(SO2)、二氧化氮(NO2)、一氧化碳(CO)和臭氧(O3)。我们应用了一个以出生体重为连续变量的线性模型。该模型根据已知的风险因素和地区进行了调整。我们按三个月评估污染物的影响，以确定关注的生物暴露窗口，并探索由于种族/民族而产生的相互作用。环境污染物二氧化硫和臭氧浓度的四分位数增加分别与出生体重下降4.99克(95%可信区间1.87-8.11)和2.72克(95%可信区间1.11-4.33)有关。较低的出生体重与怀孕第一和第二个月接触臭氧有关，而对于怀孕三个月的其他污染物，结果并不显著。在怀孕的前三个月，PM2.5显示出正相关。对PM10和PM2.5的影响估计在种族/族裔群体中是不一致的。目前的环境空气污染水平可能会增加一些污染物出生时体重较低的风险。对于某些种族/民族群体来说，这些风险可能会增加。需要进行更多的研究，包括考虑改进方法，以调查这些发现。未来的研究应该考察残差混杂的影响。
Previous studies have explored the association between air pollution levels and adverse birth outcomes such as lower birth weight. Existing literature suggests an association, although results across studies are not consistent. Additional research is needed to confirm the effect, investigate the exposure window of importance, and distinguish which pollutants cause harm. We assessed the association between ambient pollutant concentrations and term birth weight for 1,548,904 births in TX from 1998 to 2004. Assignment of prenatal exposure to air pollutants was based on maternal county of residence at the time of delivery. Pollutants examined included particulate matter with aerodynamic diameter ≤10 and ≤2.5 μm (PM10 and PM2.5), sulfur dioxide (SO2), nitrogen dioxide (NO2), carbon monoxide (CO), and ozone (O3). We applied a linear model with birth weight as a continuous variable. The model was adjusted for known risk factors and region. We assessed pollutant effects by trimester to identify biological exposure window of concern, and explored interaction due to race/ethnicity. An interquartile increase in ambient pollutant concentrations of SO2 and O3 was associated with a 4.99-g (95% confidence interval [CI], 1.87–8.11) and 2.72-g (95% CI, 1.11–4.33) decrease in birth weight, respectively. Lower birth weight was associated with exposure to O3 in the first and second trimester, whereas results were not significant for other pollutants by trimester. A positive association was exhibited for PM2.5 in the first trimester. Effects estimates for PM10 and PM2.5 were inconsistent across race/ethnic groups. Current ambient air pollution levels may be increasing the risk of lower birth weight for some pollutants. These risks may be increased for certain racial/ethnic groups. Additional research including consideration of improved methodology is needed to investigate these findings. Future studies should examine the influence of residual confounding.
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美国健康效应研究中PM（2.5）化学成分的空间和时间变化。
影响因子：
10.4
作者：
Bell ML;Dominici F;Ebisu K;Zeger SL;Samet JM
通讯作者：
Samet JM
DOI：
10.1097/ede.0b013e3181f2f405
发表时间：
2010-11
期刊：
Epidemiology (Cambridge, Mass.)
影响因子：
--
作者：
Bell ML;Belanger K;Ebisu K;Gent JF;Lee HJ;Koutrakis P;Leaderer BP
通讯作者：
Leaderer BP
影响因子：
10.4
作者：
Jedrychowski, Wieslaw;Bendkowska, Ivona;Flak, Elzbieta;Penar, Agnieszka;Jacek, Ryszard;Kaim, Irena;Spengler, John D;Camann, David;Perera, Frederica P
通讯作者：
Perera, Frederica P
影响因子：
8
作者：
Alexander, GR;Kogan, M;Mor, J
通讯作者：
Mor, J
影响因子：
8.3
作者：
Chen, Lei;Bell, Erin M.;Lin, Shao
通讯作者：
Lin, Shao