The medial prefrontal cortex is needed for resolving interference even when there are no changes in task rules and strategies.
The medial prefrontal cortex is needed for resolving interference even when there are no changes in task rules and strategies.
复制标题
即使任务规则和策略没有变化，内侧前额叶皮层也需要解决干扰。
DOI：
10.1037/bne0000347
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发表时间：
2020
影响因子：
1.9
通讯作者：
Smith,DavidM
中科院分区：
文献类型：
--
作者：
Peters,GregoryJ;Smith,DavidM
前额叶皮层（PFC）在行为灵活性中起着关键作用，解决冲突的能力，从改变策略，任务规则或注意力需求似乎是PFC功能的标志。冲突也发生在记忆领域，前额叶皮层在科普竞争性提取目标之间的干扰的能力中起着重要作用。以往的研究往往涉及干扰和任务要求的变化，这使得很难确定记忆干扰本身参与PFC处理的程度。我们在两种条件下训练大鼠连续匹配样本任务，这两种条件在干扰量方面存在差异，但不是任务要求，并发现内侧PFC的暂时失活在高干扰条件下造成更大的损害。这一结果表明，PFC在解决干扰中起着重要的作用，这可以从它在转移任务需求中的作用区分开来。
The prefrontal cortex (PFC) plays a key role in behavioral flexibility, and the ability to resolve conflict from shifting strategies, task rules or attentional demands seems to be a hallmark of PFC function. Conflict also occurs in the domain of memory and the PFC plays an important role in the ability to cope with interference between competing retrieval targets. Previous studies often involved both interference and changes in task demands, which makes it difficult to determine the degree to which mnemonic interference per se engages PFC processing. We trained rats on a continuous matching to sample task in two conditions that varied in terms of the amount of interference present but not the task demands and found that temporary inactivation of the medial PFC caused a greater impairment in the high-interference condition. This result suggests that the PFC plays an important role in resolving interference which can be distinguished from its role in shifting task demands.
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