Predictors of PFOA levels in a community surrounding a chemical plant.
Predictors of PFOA levels in a community surrounding a chemical plant.
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DOI：
10.1289/ehp.0800294
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发表时间：
2009-07
影响因子：
10.4
通讯作者：
Fletcher T
中科院分区：
文献类型：
--
作者：
Steenland K;Jin C;MacNeil J;Lally C;Ducatman A;Vieira V;Fletcher T
全氟辛酸（PFOA）被美国环境保护署认为是一种可能的人类致癌物。它在自然界中并不存在，但自第二次世界大战以来被广泛使用。它存在于大多数美国人的血清中，浓度约为4-5 ng/mL，但暴露途径仍然未知。我们研究了居住在俄亥俄州中部山谷的居民中PFOA的预测因子，该居民居住在一家化工厂附近，直到最近才向环境中释放大量PFOA，污染饮用水。我们研究了六个受污染水域的69，030名居民，他们参加了2005-2006年的调查，包括问卷和血液测试。其中，64，251人有关于PFOA和协变量的完整数据。我们还分析了一个子集（71%），我们有职业史。我们运行线性回归模型来确定血清PFOA预测因子。平均PFOA血清水平为83.0 ng/mL（中位数，28.2）。最重要的预测因子是目前（所有地区的中位数，38.4;最高区，224.1）和过去（中位数，18.6）居住在污染水域，目前（中位数，147.8）和过去（中位数，74.9）在化工厂就业（R2模型= 0.55）。男性、食用当地蔬菜的人和使用井水而不是公共水的人的PFOA较高，使用瓶装水的人较低。PFOA在较年轻和较年长的年龄更高。该人群中的全氟辛酸水平因居住地与工厂的距离和工厂的就业情况而异。年龄和性别的影响反映了先前的研究结果。其他人口统计学和生活方式协变量的影响相对较弱。
Perfluorooctanoic acid (PFOA) is considered a probable human carcinogen by the U.S. Environmental Protection Agency. It does not exist in nature but has been used widely since World War II. It is present in the serum of most Americans at about 4–5 ng/mL, although the routes of exposure remain unknown. We examined predictors of PFOA in mid-Ohio Valley residents living near a chemical plant that until recently released large quantities of PFOA into the environment, contaminating drinking water. We studied 69,030 residents in six contaminated water districts who participated in a 2005–2006 survey involving a questionnaire and blood tests. Of these, 64,251 had complete data on PFOA and covariates. We also analyzed a subset (71%) for whom we had occupational history. We ran linear regression models to determine serum PFOA predictors. Mean PFOA serum level was 83.0 ng/mL (median, 28.2). The most important predictors were current (median for all districts, 38.4; highest district, 224.1) and past (median, 18.6) residence in contaminated water districts, and current (median, 147.8) and past (median, 74.9) employment at the chemical plant (R2 model = 0.55). PFOA was higher for males, those consuming local vegetables, and those using well water rather than public water, and lower for those using bottled water. PFOA was higher at younger and older ages. PFOA levels in this population varied with distance of residence from the plant and employment at the plant. Effects of age and sex reflected prior findings. Effects of other demographic and lifestyle covariates were relatively weak.
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影响因子：
10.4
作者：
Calafat, Antonia M;Wong, Lee-Yang;Kuklenyik, Zsuzsanna;Reidy, John A;Needham, Larry L
通讯作者：
Needham, Larry L
影响因子：
5.6
作者：
Leonard, Robin C.;Kreckmann, Kim H.;Symons, J. Morel
通讯作者：
Symons, J. Morel
影响因子：
8.3
作者：
Longnecker, Matthew P.;Smith, Cynthia S.;Studabaker, William B.
通讯作者：
Studabaker, William B.
影响因子：
8.8
作者：
Olsen, Geary W.;Mair, David C.;Zobel, Larry R.
通讯作者：
Zobel, Larry R.
影响因子：
8.3
作者：
Ehresman, David J.;Froehlich, John W.;Butenhoff, John L.
通讯作者：
Butenhoff, John L.