Multiple mechanisms shape the relationship between pathway and duration of focal seizures.
Multiple mechanisms shape the relationship between pathway and duration of focal seizures.
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DOI：
10.1093/braincomms/fcac173
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发表时间：
2022
影响因子：
4.8
通讯作者：
中科院分区：
文献类型：
--
作者：
癫痫发作的电图动力学的特征是其时空演变，也称为动态“路径”，以及完成该路径所需的时间，这导致癫痫发作的持续时间。在同一个病人身上，癫痫发作的途径和持续时间都是不同的。然而，尚不清楚遵循相同途径的癫痫发作是否会有相同的持续时间，或者这些特征是否可以独立变化。我们比较了这些癫痫发作特征的受试者内部变异性，使用(i) 31例患者的癫痫监测单元颅内脑电图（iEEG）记录（平均：6.7天，16.5次发作/受试者），（ii） 10例患者的NeuroVista慢性iEEG记录（平均：521.2天，252.6次发作/受试者）和（iii） 3只局灶性癫痫发作犬的慢性iEEG记录（平均：324.4天，62.3次发作/受试者）。虽然癫痫发作途径和持续时间之间的关系强度是高度特定于受试者的，但在大多数受试者中，癫痫发作途径的变化与癫痫发作持续时间的差异只有弱至中度的相关性。癫痫发作途径和持续时间之间的关系被其他癫痫发作的途径和持续时间的“截断”版本所加强。然而，如果癫痫发作有共同的途径，但持续时间不同（“弹性”），或者持续时间相似，但遵循不同的途径（“相似”），这种关系就会减弱。即使在短时间和长时间癫痫发作的不同人群中，癫痫发作持续时间也不是不同癫痫发作途径的可靠指标。这些发现表明癫痫发作途径和持续时间是由多种不同的机制调节的。揭示这些机制可能会揭示新的治疗靶点，以减少癫痫发作的持续时间和严重程度。Schroeder等人研究了癫痫发作持续时间与癫痫发作期间活动模式序列（称为“癫痫通路”）之间的关系。他们发现了多种调节这种关系的机制，并得出结论，癫痫发作的持续时间通常不是其途径的可靠指标。
A seizure’s electrographic dynamics are characterized by its spatiotemporal evolution, also termed dynamical ‘pathway’, and the time it takes to complete that pathway, which results in the seizure’s duration. Both seizure pathways and durations have been shown to vary within the same patient. However, it is unclear whether seizures following the same pathway will have the same duration or if these features can vary independently. We compared within-subject variability in these seizure features using (i) epilepsy monitoring unit intracranial EEG (iEEG) recordings of 31 patients (mean: 6.7 days, 16.5 seizures/subject), (ii) NeuroVista chronic iEEG recordings of 10 patients (mean: 521.2 days, 252.6 seizures/subject) and (iii) chronic iEEG recordings of three dogs with focal-onset seizures (mean: 324.4 days, 62.3 seizures/subject). While the strength of the relationship between seizure pathways and durations was highly subject-specific, in most subjects, changes in seizure pathways were only weakly to moderately associated with differences in seizure durations. The relationship between seizure pathways and durations was strengthened by seizures that were ‘truncated’ versions, both in pathway and duration, of other seizures. However, the relationship was weakened by seizures that had a common pathway, but different durations (‘elasticity’), or had similar durations, but followed different pathways (‘semblance’). Even in subjects with distinct populations of short and long seizures, seizure durations were not a reliable indicator of different seizure pathways. These findings suggest that seizure pathways and durations are modulated by multiple different mechanisms. Uncovering such mechanisms may reveal novel therapeutic targets for reducing seizure duration and severity. Schroeder et al. investigated the relationship between epileptic seizure duration and the sequence of activity patterns during a seizure (termed ‘seizure pathway’). They found multiple mechanisms modulating the relationship, and concluded that the duration of a seizure is generally not a reliable indicator of its pathway.
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DOI：
10.1016/j.seizure.2015.08.004
发表时间：
2015-11
期刊：
Seizure
影响因子：
--
作者：
Afra P;Jouny CC;Bergey GK
通讯作者：
Bergey GK
DOI：
10.14581/jer.11011
发表时间：
2011-12
期刊：
Journal of epilepsy research
影响因子：
--
作者：
Kim D;Cho JW;Lee J;Joo EY;Hong SC;Hong SB;Seo DW
通讯作者：
Seo DW
影响因子：
2.2
作者：
Davis, Kathryn A.;Sturges, Beverly K.;Vite, Charles H.;Ruedebusch, Vanessa;Worrell, Gregory;Gardner, Andrew B.;Leyde, Kent;Sheffield, W. Douglas;Litt, Brian
通讯作者：
Litt, Brian
DOI：
10.1016/0013-4694(94)00286-t
发表时间：
1995-05-01
期刊：
ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY
影响因子：
--
作者：
ALARCON, G;BINNIE, CD;POLKEY, CE
通讯作者：
POLKEY, CE
影响因子：
2.2
作者：
Enatsu, Rei;Jin, Kazutaka;Nair, Dileep R.
通讯作者：
Nair, Dileep R.