Cadmium Exposure Disrupts Periodontal Bone in Experimental Animals: Implications for Periodontal Disease in Humans.
Cadmium Exposure Disrupts Periodontal Bone in Experimental Animals: Implications for Periodontal Disease in Humans.
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DOI：
10.3390/toxics6020032
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发表时间：
2018-06-13
期刊：
影响因子：
4.6
通讯作者：
Edwards JR
中科院分区：
文献类型：
--
作者：
Browar AW;Koufos EB;Wei Y;Leavitt LL;Prozialeck WC;Edwards JR
镉（Cd）是一种环境污染物，会损害肾脏、肝脏和骨骼。一些流行病学研究表明镉暴露与牙周病之间存在关联。本研究旨在探讨镉暴露与实验动物牙周病的关系。雄性Sprague/道利大鼠每天皮下注射镉（0.6毫克/公斤/天），长达12周。对动物实施安乐死，并通过测量牙骨质-牙釉质交界处（CEJ）至磨牙根的牙槽骨嵴（ABC）的距离，评价其下颌骨和上颌骨的牙周骨水平。与对照组相比，动物暴露12周后，上颌磨牙腭侧和下颌磨牙舌侧的CEJ和ABC之间的距离显著增大（p < 0.0001）。这项研究表明，镉有显着的，时间依赖性的影响，牙周骨在镉暴露的动物模型。这些研究结果支持的可能性，镉是一个促进因素的发展，牙周病在人类。
Cadmium (Cd) is an environmental contaminant that damages the kidney, the liver, and bones. Some epidemiological studies showed associations between Cd exposure and periodontal disease. The purpose of this study was to examine the relationship between Cd exposure and periodontal disease in experimental animals. Male Sprague/Dawley rats were given daily subcutaneous injections of Cd (0.6 mg/kg/day) for up to 12 weeks. The animals were euthanized, and their mandibles and maxillae were evaluated for levels of periodontal bone by measuring the distance from the cementoenamel junction (CEJ) to the alveolar bone crest (ABC) of the molar roots. After 12 weeks of Cd exposure in animals, there was a significantly greater distance between the CEJ and ABC in the palatal aspect of the maxillary molars and the lingual aspect of the mandibular molars when compared with controls (p < 0.0001). This study shows that Cd has significant, time-dependent effects on periodontal bone in an animal model of Cd exposure. These findings support the possibility of Cd being a contributing factor to the development of periodontal disease in humans.
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DOI：
10.5455/msm.2012.24.274-276
发表时间：
2012
期刊：
Materia socio-medica
影响因子：
--
作者：
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通讯作者：
Borojevic T
影响因子：
3.8
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影响因子：
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DOI：
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发表时间：
2013-07-01
影响因子：
3
作者：
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通讯作者：
Lee, Byung-Kook
影响因子：
4.5
作者：
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