CIPRO 2.5: Ciona intestinalis protein database, a unique integrated repository of large-scale omics data, bioinformatic analyses and curated annotation, with user rating and reviewing functionality.
CIPRO 2.5: Ciona intestinalis protein database, a unique integrated repository of large-scale omics data, bioinformatic analyses and curated annotation, with user rating and reviewing functionality.
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DOI：
10.1093/nar/gkq1144
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发表时间：
2011-01
影响因子：
14.9
通讯作者：
Inaba K
中科院分区：
文献类型：
--
作者：
Endo T;Ueno K;Yonezawa K;Mineta K;Hotta K;Satou Y;Yamada L;Ogasawara M;Takahashi H;Nakajima A;Nakachi M;Nomura M;Yaguchi J;Sasakura Y;Yamasaki C;Sera M;Yoshizawa AC;Imanishi T;Taniguchi H;Inaba K
CIPRO （Ciona testinalis protein database）是被囊动物C. testinalis的蛋白质数据库。该数据库在两个方面是独一无二的：首先，由于其系统发育位置，Ciona是理解脊椎动物进化的合适模型；其次，该数据库包含原始的大规模转录组学和蛋白质组学数据。鸡肠草也是发育生物学家的最爱。因此，有大量关于其发育和形态的数据，以及最近的基因组序列和基因表达数据。CIPRO数据库旨在收集那些已发表的数据，并从未发表的实验数据中提供独特的信息，例如在不同发育阶段的3D表达谱、2D-PAGE和基于质谱的大规模分析、精心整理的注释数据和各种生物信息学数据，以促进不同领域的研究，包括发育生物学、比较生物学和进化生物学。对于医学和进化研究，有意将人类和主要模式生物的同源物包括在内。目前的数据库是基于最近开发的包含36034个独特序列的KH模型，但为了提高可用性，它涵盖了该物种所有基因模型中已知和预测的86983个蛋白质。在这些序列中，超过10,000个蛋白质已经被手工注释。此外，为了建立一个社区支持的蛋白质数据库，这些注释将通过CIPRO网站开放给用户评价。CIPRO 2.5可在http://cipro.ibio.jp/2.5免费获取。
The Ciona intestinalis protein database (CIPRO) is an integrated protein database for the tunicate species C. intestinalis. The database is unique in two respects: first, because of its phylogenetic position, Ciona is suitable model for understanding vertebrate evolution; and second, the database includes original large-scale transcriptomic and proteomic data. Ciona intestinalis has also been a favorite of developmental biologists. Therefore, large amounts of data exist on its development and morphology, along with a recent genome sequence and gene expression data. The CIPRO database is aimed at collecting those published data as well as providing unique information from unpublished experimental data, such as 3D expression profiling, 2D-PAGE and mass spectrometry-based large-scale analyses at various developmental stages, curated annotation data and various bioinformatic data, to facilitate research in diverse areas, including developmental, comparative and evolutionary biology. For medical and evolutionary research, homologs in humans and major model organisms are intentionally included. The current database is based on a recently developed KH model containing 36 034 unique sequences, but for higher usability it covers 89 683 all known and predicted proteins from all gene models for this species. Of these sequences, more than 10 000 proteins have been manually annotated. Furthermore, to establish a community-supported protein database, these annotations are open to evaluation by users through the CIPRO website. CIPRO 2.5 is freely accessible at http://cipro.ibio.jp/2.5.
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影响因子：
0.9
作者：
Azumi, K;Takahashi, H;Satoh, N
通讯作者：
Satoh, N
影响因子：
14.9
作者：
Hulo, N;Sigrist, CJA;Bairoch, A
通讯作者：
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影响因子：
--
作者：
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通讯作者：
Inaba, Kazuo
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影响因子：
14.9
作者：
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通讯作者：
Nakai, Kenta
影响因子：
2.7
作者：
Nomura, Mamoru;Nakajima, Ayako;Inaba, Kazuo
通讯作者：
Inaba, Kazuo