Host cell remodeling by pathogens: the exomembrane system in Plasmodium-infected erythrocytes.
Host cell remodeling by pathogens: the exomembrane system in Plasmodium-infected erythrocytes.
复制标题
DOI：
10.1093/femsre/fuw016
复制
发表时间：
2016-09
影响因子：
11.3
通讯作者：
van Ooij C
中科院分区：
文献类型：
--
作者：
Sherling ES;van Ooij C
疟疾是由疟原虫属寄生虫感染红细胞引起的。为了在红细胞内生存，这些寄生虫会引起宿主细胞内的彻底变化，其中最引人注目的变化之一是形成多个膜室，统称为外膜系统。由于未感染的哺乳动物红细胞没有内膜，因此寄生虫必定是这些区室形成背后的力量和来源。尽管这些内部隔室存在的第一个证据是在一个多世纪前获得的，但它们的功能仍然大多不清楚，在某些情况下完全未知，并且它们形成的机制仍然是神秘的。在这篇综述中，我们概述了外膜系统的不同部分，描述了寄生液泡、管泡网络、毛雷尔裂隙、小窝囊泡复合体、J点和其他移动区室，以及在疟原虫感染的细胞中观察到的小囊泡。最后，我们将数据组合成外膜系统及其与宿主红细胞变化的关系的简化视图。疟原虫寄生虫以多种方式重塑宿主红细胞，包括在红细胞胞质内形成几个膜室（统称为外膜系统），这些膜室共同是宿主细胞发生彻底变化的关键。
Malaria is caused by infection of erythrocytes by parasites of the genus Plasmodium. To survive inside erythrocytes, these parasites induce sweeping changes within the host cell, one of the most dramatic of which is the formation of multiple membranous compartments, collectively referred to as the exomembrane system. As an uninfected mammalian erythrocyte is devoid of internal membranes, the parasite must be the force and the source behind the formation of these compartments. Even though the first evidence of the presence these of internal compartments was obtained over a century ago, their functions remain mostly unclear, and in some cases completely unknown, and the mechanisms underlying their formation are still mysterious. In this review, we provide an overview of the different parts of the exomembrane system, describing the parasitophorous vacuole, the tubovesicular network, Maurer's clefts, the caveola-vesicle complex, J dots and other mobile compartments, and the small vesicles that have been observed in Plasmodium-infected cells. Finally, we combine the data into a simplified view of the exomembrane system and its relation to the alterations of the host erythrocyte. Plasmodium parasites remodel the host erythrocyte in various ways, including the formation of several membranous compartments, together referred to as the exomembrane system, within the erythrocyte cytosol that together are key to the sweeping changes in the host cell.
登录
查看更多内容
旋钮阳性和旋钮阴性疟原虫恶性疟原虫在感染红细胞表面的菌株特异性疟疾抗原的表达上有所不同。
影响因子：
15.3
作者：
Aley, S B;Sherwood, J A;Howard, R J
通讯作者：
Howard, R J
DOI：
10.1083/jcb.91.1.55
发表时间：
1981-10
期刊：
The Journal of cell biology
影响因子：
--
作者：
Aikawa M;Miller LH;Rabbege JR;Epstein N
通讯作者：
Epstein N
影响因子：
2.4
作者：
Bannister, L. H.;Mitchell, G. H.
通讯作者：
Mitchell, G. H.
影响因子：
3.6
作者：
Akinyi, Sheila;Hanssen, Eric;Galinski, Mary R.
通讯作者：
Galinski, Mary R.
影响因子：
3.7
作者：
Arisue, Nobuko;Kawai, Satoru;Horii, Toshihiro
通讯作者：
Horii, Toshihiro