Efficacy of Lactobacillus-supplemented triple therapy for H. pylori eradication: A meta-analysis of randomized controlled trials
Efficacy of Lactobacillus-supplemented triple therapy for H. pylori eradication: A meta-analysis of randomized controlled trials
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补充乳酸菌的三联疗法根除幽门螺杆菌的功效：随机对照试验的荟萃分析
DOI：
10.1371/journal.pone.0223309
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发表时间：
2019-10
期刊：
影响因子：
3.7
通讯作者：
Guangcai Duan
中科院分区：
文献类型：
--
作者：
Mingyang Yu;Rongguang Zhang;Peng Ni;Shuaiyin Chen;Guangcai Duan
目的评价补充乳酸杆菌对三联疗法幽门螺杆菌根除率及不良反应的影响。方法检索截至2019年7月发表的PubMed、Embase、Web of Science和Cochrane Library。采用Review Manager 5.3和Stata 12.0进行统计分析。结果初步检索得到852篇文献。通过排除筛选，最终纳入11项随机对照试验，共计724例患者。乳酸菌补充组幽门螺杆菌清除率显著高于对照组（RR 1.16, 95% CI 1.08 ~ 1.25， P<0.0001）。亚组分析显示，成人组和儿童组的根除率均显著提高，亚洲组和欧洲组之间无显著差异。此外，基于补充乳酸杆菌持续时间的亚分析显示，长期组和短期组的合并rr分别为1.17 （95%CI 1.06-1.30）和1.16 （95%CI 1.04-1.30）。对于乳酸菌菌株，干酪乳杆菌组的合并RR为1.33 (95% CI 1.10 ~ 1.62)，罗伊氏乳杆菌组的合并RR为1.18 (95% CI 1.03 ~ 1.34)， GG乳杆菌组的合并RR为1.02 （95% CI 0.87 ~ 1.21）。在总副作用方面，添加乳酸杆菌显著降低了味觉障碍的发生率（RR = 0.36, 95% CI 0.17-0.74, P = 0.005）。结论在幽门螺杆菌感染治疗过程中补充乳杆菌可有效提高幽门螺杆菌的根除率，降低治疗相关味觉障碍的发生率。
Aim To assess the effect of Lactobacillus supplementation on Helicobacter pylori eradication rates and side effects of the triple therapy. Methods PubMed, Embase, Web of Science and Cochrane Library were searched for articles published up to July, 2019. Review Manager 5.3 and Stata 12.0 were used for statistical analyses. Results The initial database search resulted in 852 articles. Through exclusion and screening, 11 randomized controlled trials involving a total of 724 patients were finally included in this meta-analysis. The H. pylori elimination rate in the Lactobacillus supplement group was significantly higher than that in the control group (RR 1.16, 95% CI 1.08–1.25, P<0.0001). Subgroup analysis showed that the eradication rates were significantly enhanced in both adults and children group, and no significant difference was detected between Asia and Europe group. In addition, sub-analysis based on duration of Lactobacillus supplementation showed the pooled RRs in the long-term and short-term groups were 1.17 (95%CI 1.06–1.30) and 1.16 (95% CI 1.04–1.30), respectively. Regarding the Lactobacillus strains, the pooled RR was 1.33 (95% CI 1.10–1.62) in the L. casei group, 1.18 (95% CI 1.03–1.34) in the L. reuteri group while 1.02 (95% CI 0.87–1.21) in the Lactobacillus GG group. As for the total side effects, Lactobacillus supplementation significantly reduced the incidence of taste disturbance (RR = 0.36, 95% CI 0.17–0.74, P = 0.005). Conclusions Lactobacillus supplementation during the treatment of Helicobacter pylori infection can effectively improve the eradication rates, and reduce the incidence of therapy-related taste disturbance.
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影响因子：
82.9
作者：
Rousseaux, Christel;Thuru, Xavier;Desreumaux, Pierre
通讯作者：
Desreumaux, Pierre
DOI：
10.1271/bbb.110921
发表时间：
2012-04
期刊：
Bioscience, Biotechnology, and Biochemistry
影响因子：
--
作者：
Hirokazu Isobe;A. Nishiyama;Tomomi Takano;W. Higuchi;S. Nakagawa;I. Taneike;Y. Fukushima;Tatsuo Yamamoto
通讯作者：
Hirokazu Isobe;A. Nishiyama;Tomomi Takano;W. Higuchi;S. Nakagawa;I. Taneike;Y. Fukushima;Tatsuo Yamamoto
影响因子：
2.9
作者：
Wang, Zhen-Hua;Gao, Qin-Yan;Fang, Jing-Yuan
通讯作者：
Fang, Jing-Yuan
DOI：
10.4321/s1130-01082012000900005
发表时间：
2012-09-01
期刊：
Revista Española de Enfermedades Digestivas
影响因子：
--
作者：
García, Apolinaria;Sáez, Katia;González, Carlos L.
通讯作者：
González, Carlos L.
影响因子：
4.3
作者：
Yang, Jyh-Chin;Lu, Chien-Wei;Lin, Chun-Jung
通讯作者：
Lin, Chun-Jung