High-frequency stimulation of the subthalamic nucleus restores neural and behavioral functions during reaction time task in a rat model of Parkinson's disease.
High-frequency stimulation of the subthalamic nucleus restores neural and behavioral functions during reaction time task in a rat model of Parkinson's disease.
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DOI：
10.1002/jnr.22313
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发表时间：
2010-05-15
影响因子：
4.2
通讯作者：
Luo, Fei
中科院分区：
文献类型：
--
作者：
Li, Xiang-Hong;Wang, Jin-Yan;Gao, Ge;Chang, Jing-Yu;Woodward, Donald J.;Luo, Fei
脑深部电刺激（DBS）已在临床上用于治疗帕金森病（PD）和其他神经精神疾病。我们以前的工作表明，丘脑底核（DBS）可以改善单侧多巴胺（DA）损伤大鼠的主要运动障碍，并诱导多种神经反应。在本研究中，我们研究了部分双侧DA损伤大鼠的反应时间（RT）性能和皮质基底神经节区域神经活动的平行变化的影响。在RT试验中，我们用多通道单单位电极系统记录了初级运动皮层（MI）、延髓和黑质网状部（SNr）的神经活动。双侧注射6-OHDA至纹状体背外侧部分后，RT性能严重受损。与此同时，DA损毁后，对不同行为事件的反应神经元数量显著减少。在6-OHDA损伤的大鼠中，双侧DBS改善了RT性能，并恢复了皮质基底神经节区域的操作行为相关神经反应。DBS的这些行为和电生理效应在DBS终止后持续近一小时。这些结果表明，部分DA损伤诱导的RT性能的损害与皮质基底神经节电路中的神经活动的变化。此外，DBS可以逆转由部分DA耗竭引起的行为和神经活动的变化。所观察到的长期有益的影响，DBS表明参与调节皮质基底神经节电路的神经可塑性的机制。
Deep brain stimulation (DBS) has been used in the clinic to treat Parkinson’s disease (PD) and other neuropsychiatric disorders. Our previous work has shown that DBS in the subthalamic nucleus (STN) can improve major motor deficits, and induce a variety of neural responses in rats with unilateral dopamine (DA) lesions. In the present study, we examined the effect of STN DBS on reaction time (RT) performance and parallel changes in neural activity in the cortico-basal ganglia regions of partially bilateral DA- lesioned rats. We recorded neural activity with a multiple-channel single-unit electrode system in the primary motor cortex (MI), the STN, and the substantia nigra pars reticulata (SNr) during RT test. RT performance was severely impaired following bilateral injection of 6-OHDA into the dorsolateral part of the striatum. In parallel with such behavioral impairments, the number of responsive neurons to different behavioral events was remarkably decreased after DA lesion. Bilateral STN DBS improved RT performance in 6-OHDA lesioned rats, and restored operational behavior-related neural responses in cortico-basal ganglia regions. These behavioral and electrophysiological effects of DBS lasted nearly an hour after DBS termination. These results demonstrate that a partial DA lesion-induced impairment of RT performance is associated with changes in neural activity in the cortico-basal ganglia circuit. Furthermore, STN DBS can reverse changes in behavior and neural activity caused by partial DA depletion. The observed long-lasting beneficial effect of STN DBS suggests the involvement of the mechanism of neural plasticity in modulating corticobasal ganglia circuits.
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影响因子：
2.9
作者：
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