The summating potential polarity encodes the ear health condition.
The summating potential polarity encodes the ear health condition.
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DOI：
10.1007/s00018-023-04809-5
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发表时间：
2023-05-24
影响因子：
8
通讯作者：
Hakizimana, Pierre
中科院分区：
文献类型：
--
作者：
Hakizimana, Pierre
关键词：
总和电位（SP）是毛细胞将声音的振动机械能转换成电信号时产生的DC电位，其沿着AC响应，是耳蜗电位中最神秘的，因为其极性和功能在七十多年来一直难以捉摸。尽管噪声引起的听力损失的巨大的社会经济后果和深刻的生理重要性，了解响亮的噪声暴露如何损害毛细胞受体激活，SP和噪声引起的听力损伤之间的关系仍然很差的特点。在这里，我表明，在正常听力的耳朵，SP极性是积极的，其幅度相对于AC响应的增长呈指数级的频率，并成为负的，并呈指数级下降的频率以下噪声引起的听力损伤。由于SP被认为是由K+流出通过毛细胞基底外侧K+通道的梯度下降产生的，SP极性切换到负值与毛细胞工作点的噪声诱导的偏移一致。在线版本包含补充材料，可通过10.1007/s 00018 -023-04809-5获得。
The summating potential (SP), the DC potential which, along with the AC response, is produced when the hair cells convert the vibrational mechanical energy of sound into electrical signals, is the most enigmatic of the cochlear potentials because its polarity and function have remained elusive for more than seven decades. Despite the tremendous socioeconomic consequences of noise-induced hearing loss and the profound physiological importance of understanding how loud noise exposure impairs the hair cell receptor activation, the relationship between the SP and noise-induced hearing impairment remains poorly characterized. Here, I show that in normally hearing ears, the SP polarity is positive and its amplitude relative to the AC response grows exponentially across frequencies, and becomes negative and decreases exponentially across frequencies following noise-induced hearing injury. Since the SP is thought to be generated by K+ outflow down the gradient through the hair cell basolateral K+ channels, the SP polarity switch to negative values is consistent with a noise-induced shift in the operating point of the hair cells. The online version contains supplementary material available at 10.1007/s00018-023-04809-5.
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影响因子：
8.1
作者：
Dillard, Lauren K.;Arunda, Malachi Ochieng;Lopez-Perez, Lucero;Martinez, Ricardo X.;Jimenez, Lucia;Chadha, Shelly
通讯作者：
Chadha, Shelly
影响因子：
13.6
作者：
通讯作者：
--
影响因子：
16.6
作者：
Hakizimana P;Fridberger A
通讯作者：
Fridberger A
DOI：
10.1098/rspb.1997.0087
发表时间：
1997-04-22
影响因子：
4.7
作者：
Geleoc, GSG;Lennan, GWT;Kros, CJ
通讯作者：
Kros, CJ
影响因子：
5.5
作者：
HOLTON, T;HUDSPETH, AJ
通讯作者：
HUDSPETH, AJ