Planarians sense simulated microgravity and hypergravity.
Planarians sense simulated microgravity and hypergravity.
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DOI：
10.1155/2014/679672
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发表时间：
2014
影响因子：
--
通讯作者：
Auletta G
中科院分区：
文献类型：
--
作者：
Adell T;Saló E;van Loon JJ;Auletta G
Planarians是扁形虫，属于扁形动物门。由于它们惊人的再生能力，它们一直是经典的研究对象，这种再生能力依赖于成体全能干细胞的存在。如今，它们是发育、再生和干细胞生物学领域的新兴模型系统。本研究分析了模拟微重力和超重力环境对真涡虫再生和胚胎发生过程的影响。我们用随机定位机（RPM）模拟微重力，速度设定为60 °/s，而不是10 °/s，结果显示出真涡虫的死亡。在3克和4克的超重力下，在一个大直径离心机（LDC）的涡虫可以再生缺失的组织，虽然观察到增殖率下降。在8 g超重力下，小的真涡虫碎片不能再生。此外，我们还发现了重力变化对涡虫分裂率的影响，这是它的无性繁殖模式。在胚胎发育过程中，没有发现明显的重力变化的影响。
Planarians are flatworms, which belong to the phylum Platyhelminthes. They have been a classical subject of study due to their amazing regenerative ability, which relies on the existence of adult totipotent stem cells. Nowadays they are an emerging model system in the field of developmental, regenerative, and stem cell biology. In this study we analyze the effect of a simulated microgravity and a hypergravity environment during the process of planarian regeneration and embryogenesis. We demonstrate that simulated microgravity by means of the random positioning machine (RPM) set at a speed of 60 °/s but not at 10 °/s produces the dead of planarians. Under hypergravity of 3 g and 4 g in a large diameter centrifuge (LDC) planarians can regenerate missing tissues, although a decrease in the proliferation rate is observed. Under 8 g hypergravity small planarian fragments are not able to regenerate. Moreover, we found an effect of gravity alterations in the rate of planarian scission, which is its asexual mode of reproduction. No apparent effects of altered gravity were found during the embryonic development.
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影响因子：
0.7
作者：
Fraguas, Susanna;Barberan, Sara;Cebria, Francesc
通讯作者：
Cebria, Francesc
影响因子：
2.9
作者：
Uva, BM;Masini, MA;Strollo, F
通讯作者：
Strollo, F
影响因子：
0.7
作者：
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通讯作者：
Crawford-Young, SJ
影响因子：
1.8
作者：
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通讯作者：
van Loon, Jack J. W. A.
DOI：
10.1073/pnas.96.9.5049
发表时间：
1999-04-27
影响因子：
11.1
作者：
Alvarado, AS;Newmark, PA
通讯作者：
Newmark, PA