Mobilising vitamin D from adipose tissue: The potential impact of exercise.
Mobilising vitamin D from adipose tissue: The potential impact of exercise.
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DOI：
10.1111/nbu.12369
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发表时间：
2019-03
影响因子：
3.3
通讯作者：
Thompson D
中科院分区：
文献类型：
--
作者：
Hengist A;Perkin O;Gonzalez JT;Betts JA;Hewison M;Manolopoulos KN;Jones KS;Koulman A;Thompson D
维生素D是亲脂性的，并大量积累在脂肪组织中。即使没有补充，一个典型成年人脂肪中的维生素D含量也相当于几个月的每日参考营养素摄入量（RNI）。矛盾的是，尽管脂肪组织中含有大量维生素D，但根据维生素D状态的共识指标（血清25-羟基维生素D浓度），肥胖者往往缺乏维生素D。因此，似乎维生素D可能被“捕获”在脂肪组织中，这可能是由于不充分的脂解刺激和/或由于脂肪扩张导致的组织功能障碍/适应。新出现的证据表明，运动可以从脂肪中动员维生素D（即使没有减肥）。如果运动有助于从脂肪组织中动员维生素D，那么这可能会对从业者和决策者在管理低循环水平的维生素D以及长期低水平的体力活动，肥胖和相关健康状况方面产生重要影响。这一观点促使我们设计了一项研究，以检查运动对维生素D状态，维生素D周转和脂肪组织维生素D含量的影响（VitaDEx项目）。VitaDEx项目将确定增加体力活动（通过锻炼）是否是从脂肪组织中动员维生素D的潜在有用策略。
Vitamin D is lipophilic and accumulates substantially in adipose tissue. Even without supplementation, the amount of vitamin D in the adipose of a typical adult is equivalent to several months of the daily reference nutrient intake (RNI). Paradoxically, despite the large amounts of vitamin D located in adipose tissue, individuals with obesity are often vitamin D deficient according to consensus measures of vitamin D status (serum 25‐hydroxyvitamin D concentrations). Thus, it appears that vitamin D can become ‘trapped’ in adipose tissue, potentially due to insufficient lipolytic stimulation and/or due to tissue dysfunction/adaptation resulting from adipose expansion. Emerging evidence suggests that exercise may mobilise vitamin D from adipose (even in the absence of weight loss). If exercise helps to mobilise vitamin D from adipose tissue, then this could have important ramifications for practitioners and policymakers regarding the management of low circulating levels of vitamin D, as well as chronically low levels of physical activity, obesity and associated health conditions. This perspective led us to design a study to examine the impact of exercise on vitamin D status, vitamin D turnover and adipose tissue vitamin D content (the VitaDEx project). The VitaDEx project will determine whether increasing physical activity (via exercise) represents a potentially useful strategy to mobilise vitamin D from adipose tissue.
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影响因子：
6.2
作者：
Carrelli, Angela;Bucovsky, Mariana;Stein, Emily M.
通讯作者：
Stein, Emily M.
影响因子：
2.9
作者：
BLUNT, JW;DELUCA, HF
通讯作者：
DELUCA, HF
DOI：
10.3945/ajcn.115.120873
发表时间：
2016-04
期刊：
The American journal of clinical nutrition
影响因子：
--
作者：
Cashman KD;Dowling KG;Škrabáková Z;Gonzalez-Gross M;Valtueña J;De Henauw S;Moreno L;Damsgaard CT;Michaelsen KF;Mølgaard C;Jorde R;Grimnes G;Moschonis G;Mavrogianni C;Manios Y;Thamm M;Mensink GB;Rabenberg M;Busch MA;Cox L;Meadows S;Goldberg G;Prentice A;Dekker JM;Nijpels G;Pilz S;Swart KM;van Schoor NM;Lips P;Eiriksdottir G;Gudnason V;Cotch MF;Koskinen S;Lamberg-Allardt C;Durazo-Arvizu RA;Sempos CT;Kiely M
通讯作者：
Kiely M
影响因子：
3.9
作者：
Adams, J. S.;Hewison, M.
通讯作者：
Hewison, M.
影响因子：
3.7
作者：
Blum, Miriam;Dolnikowski, Gregory;Dawson-Hughes, Bess
通讯作者：
Dawson-Hughes, Bess