Anti-Inflammatory Effect of 3,4-Oxo-isopropylidene-shikimic Acid on Acetic Acid-Induced Colitis in Rats
Anti-Inflammatory Effect of 3,4-Oxo-isopropylidene-shikimic Acid on Acetic Acid-Induced Colitis in Rats
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3,4-氧代异丙叉莽草酸对乙酸诱导的大鼠结肠炎的抗炎作用
DOI：
10.1007/s10753-012-9509-7
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发表时间：
2012-07
期刊：
影响因子：
5.1
通讯作者：
Ya-Lin Dong
中科院分区：
文献类型：
--
作者：
Jian-Feng Xing;Jian-Ning Sun;Jin-Yao Sun;Cui-Yu You;Kai Dong;Jun Lv;Ya-Lin Dong
本文研究了3，4-氧代异亚丙基莽草酸（伊萨）对乙酸（AA）诱导的大鼠结肠炎的可能作用。结肠内注射6%AA诱发结肠炎.确定了几个参数，包括宏观评分和生化参数，以评估保护程度。生化参数，如髓过氧化物酶（MPO）活性，丙二醛（MDA）和一氧化氮（NO）的水平，超氧化物歧化酶（SOD）和诱导型NO合酶（NOS）的活性进行了测定后的标准分析程序。研究表明，用伊萨（100和200 mg/kg）处理大鼠6天能够完全保护大鼠免受AA诱导的结肠炎。此外，生化变化被逆转，并走向控制。这些结果表明伊萨对实验性结肠炎的有益作用，其保护作用的可能机制可能部分是由于抗氧化作用。
The present work was done to investigate the possible effects of 3,4-oxo-isopropylidene-shikimic acid (ISA) on acetic acid (AA)-induced colitis in rats. Colitis was induced by intracolonic injection of 6 % AA. Several parameters, including macroscopic score and biochemical parameters, were determined to assess the degree of protection. Biochemical parameters such as myeloperoxidase (MPO) activity, malondialdehyde (MDA) and nitric oxide (NO) levels, and superoxide dismutase (SOD) and inducible NO synthase (NOS) activities were measured following standard assay procedures. The study showed that treatment of rats for 6 days with ISA (100 and 200 mg/kg) was able to give complete protection against AA-induced colitis. Moreover, biochemical changes were reversed and brought toward control. These results suggest a beneficial effect of ISA against experimental colitis and the possible mechanism of the protective effects may be partly due to an antioxidant action.
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DOI：
--
发表时间：
2007
期刊：
Journal of Beijing University of Traditional Chinese Medicine
影响因子：
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作者：
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通讯作者：
Sun Jian-ning
影响因子：
3.9
作者：
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影响因子：
2.8
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通讯作者：
Toker, Gulcin Aykac
DOI：
--
发表时间：
2002-04
期刊：
Yao xue xue bao = Acta pharmaceutica Sinica
影响因子：
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作者：
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