Age-related effect of serotonin transporter genotype on amygdala and prefrontal cortex function in adolescence.
Age-related effect of serotonin transporter genotype on amygdala and prefrontal cortex function in adolescence.
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DOI：
10.1002/hbm.22208
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发表时间：
2014-02
影响因子：
4.8
通讯作者：
Monk, Christopher S.
中科院分区：
文献类型：
--
作者：
Wiggins, Jillian Lee;Bedoyan, Jirair K.;Carrasco, Melisa;Swartz, Johnna R.;Martin, Donna M.;Monk, Christopher S.
5-羟色胺转运蛋白连锁多态性区域（5-HTTLPR）的S和LG等位基因降低5-羟色胺转运蛋白表达。这些低表达等位基因与抑郁症风险增加和抑郁症中发现的大脑激活模式（杏仁核激活增加和杏仁核-前额叶皮层连接减少）有关。奇怪的是，5-羟色胺转运体阻滞剂可以缓解抑郁症状。啮齿类动物模型表明，在生命早期血清素转运蛋白减少会导致青春期出现的抑郁症，而在发育后期出现的血清素转运蛋白减少会改善抑郁症。然而，还没有脑成像研究调查人类发育对5-HTTLPR和情感相关脑功能之间联系的调节作用。我们研究了5-HTTLPR对9-19岁儿童和青少年杏仁核激活和杏仁核-前额叶皮层连接的年龄相关影响，使用重复性良好的探针，情绪面孔任务。一个显着的基因型与年龄的相互作用预测杏仁核的激活，使低表达基因型（S/S，S/LG）组表现出更大的增加杏仁核的激活与年龄相比，较高的表达（LA/LA，S/LA）组。此外，与高表达组相比，低表达基因型组的右杏仁核和腹内侧前额叶皮质之间的连接随着年龄的增长而减少。研究结果表明，低表达基因型可能不会导致皮质边缘功能与抑郁症的风险，直到后来的青春期。
The S and LG alleles of the serotonin transporter-linked polymorphic region (5-HTTLPR) lower serotonin transporter expression. These low expressing alleles are linked to increased risk for depression and brain activation patterns found in depression (increased amygdala activation and decreased amygdala-prefrontal cortex connectivity). Paradoxically, serotonin transporter blockade relieves depression symptoms. Rodent models suggest that decreased serotonin transporter in early life produces depression that emerges in adolescence, whereas decreased serotonin transporter that occurs later in development ameliorates depression. However, no brain imaging research has yet investigated the moderating influence of human development on the link between 5-HTTLPR and affect-related brain function. We investigated the age-related effect of 5-HTTLPR on amygdala activation and amygdala-prefrontal cortex connectivity using a well-replicated probe, an emotional faces task, in children and adolescents age 9–19 years. A significant genotype-by-age interaction predicted amygdala activation such that the low expressing genotype (S/S, S/LG) group showed a greater increase in amygdala activation with age compared to the higher expressing (LA/LA, S/LA) group. Additionally, compared to the higher expressing group, the low expressing genotype group exhibited decreased connectivity between the right amygdala and ventromedial prefrontal cortex with age. Findings indicate that low expressing genotypes may not result in the cortico-limbic profile associated with depression risk until later adolescence.
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影响因子：
11
作者：
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影响因子：
3.9
作者：
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Phillips, Mary Louise
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作者：
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通讯作者：
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