Association between Blood Pressure and HIV Status in Rural Uganda: Results of Cross-Sectional Analysis.
Association between Blood Pressure and HIV Status in Rural Uganda: Results of Cross-Sectional Analysis.
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DOI：
10.5334/gh.858
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发表时间：
2021-02-10
期刊：
影响因子：
3.7
通讯作者：
Checkley W
中科院分区：
文献类型：
--
作者：
Niwaha AJ;Wosu AC;Kayongo A;Batte C;Siddharthan T;Kalyesubula R;Kirenga B;Checkley W
在撒哈拉以南非洲地区，艾滋病毒状况与高血压之间的关系尚未得到很好的描述。我们研究了生活在乌干达农村地区的HIV阳性和阴性个体中高血压的患病率和危险因素。我们对年龄≥35岁的600名HIV阴性和721名HIV血清阳性个体进行了横断面分析。在721名HIV阳性参与者中，女性占59.8%，年龄中位数为44.3岁，而在HIV阴性个体中，女性占55%，年龄中位数为47.8岁。90%以上的艾滋病毒阳性者正在接受抗逆转录病毒治疗。高血压患病率（≥140/≥90 mmHg）在HIV阴性人群中占33.5%，在HIV阳性人群中占23.9%。年龄（校正后OR = 1.05, 95% CI 1.03 ~ 1.06）和BMI（校正后OR = 1.08, 95% CI 1.05 ~ 1.12）与高血压的高发生率相关。感染HIV与较低的高血压发生率（校正OR = 0.66, 95% CI 0.50至0.88）、较低的收缩压（-5.1 mmHg, 95% CI: -7.4至-2.4）和较低的舒张压（-4.0 mmHg, 95% CI: -5.6至-2.5）相关。在该样本中，我们没有观察到CD4计数、病毒载量或抗逆转录病毒治疗在HIV阳性个体中高血压发病率的差异。高血压在三分之一的HIV阴性个体和四分之一的HIV阳性患者中普遍存在。虽然参加艾滋病毒诊所的个人获得健康信息可能解释观察到的差异，但需要进行更多的研究，以了解可能解释乌干达艾滋病毒感染者血压较低的合理生物和社会机制。
The association between HIV status and hypertension is not well described within sub-Saharan Africa. We examined prevalence and risk factors for hypertension among HIV positive and negative individuals living in a rural district of Uganda. We conducted a cross-sectional analysis in two concurrent cohorts of 600 HIV negative and 721 HIV seropositive individuals aged ≥35 years. Of the 721 HIV positive participants, 59.8% were women and the median age was 44.3 years, while for HIV negative individuals, 55% were women and the median age was 47.8 years. Over 90% of HIV positive individuals were on antiretroviral treatment. The prevalence of hypertension (≥140/≥90 mmHg) was 33.5% in HIV negative individuals and 23.9% in HIV positive individuals. Age (adjusted OR = 1.05, 95% CI 1.03 to 1.06) and BMI (adjusted OR = 1.08, 95% CI 1.05 to 1.12) were associated with higher odds of hypertension. Having HIV was associated with lower odds of hypertension (adjusted OR = 0.66, 95% CI 0.50 to 0.88), lower systolic blood pressure (–5.1 mmHg, 95% CI: –7.4 to –2.4) and lower diastolic blood pressure (–4.0 mmHg, 95% CI: –5.6 to –2.5). We did not observe differences in the odds of hypertension by CD4 count, viral load or ART among HIV positive individuals in this sample. Hypertension was prevalent in one third of HIV negative individuals and in one fourth of HIV positive patients. While access to health information among individuals attending HIV clinics may explain observed differences, more research is needed to understand plausible biological and social mechanisms that could explain lower blood pressure among people living with HIV in Uganda.
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影响因子：
8.1
作者：
Kalyesubula R;Kayongo A;Semitala FC;Muhanguzi A;Katantazi N;Ayers D;Forrest JI;Mills EJ
通讯作者：
Mills EJ
影响因子：
11.1
作者：
Siddharthan, Trishul;Grigsby, Matthew;Checkley, William
通讯作者：
Checkley, William
影响因子：
3.7
作者：
Guwatudde, David;Mutungi, Gerald;Bahendeka, Silver K.
通讯作者：
Bahendeka, Silver K.
影响因子：
2.9
作者：
Ogunmola, Olarinde Jeffrey;Oladosu, Olatunji Yusuf;Olamoyegun, Adeyemi Michael
通讯作者：
Olamoyegun, Adeyemi Michael
影响因子：
4.5
作者：
Kayima, James;Nankabirwa, Joaniter;Kamya, Moses R.
通讯作者：
Kamya, Moses R.