Inequalities in urban greenness and epigenetic aging: Different associations by race and neighborhood socioeconomic status.
Inequalities in urban greenness and epigenetic aging: Different associations by race and neighborhood socioeconomic status.
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DOI：
10.1126/sciadv.adf8140
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发表时间：
2023-06-28
期刊：
影响因子：
13.6
通讯作者：
Hou, Lifang
中科院分区：
文献类型：
--
作者：
Kim, Kyeezu;Joyce, Brian T. T.;Nannini, Drew R. R.;Zheng, Yinan;Gordon-Larsen, Penny;Shikany, James M. M.;Lloyd-Jones, Donald M. M.;Hu, Ming;Nieuwenhuijsen, Mark J. J.;Vaughan, Douglas E. E.;Zhang, Kai;Hou, Lifang
较慢的表观遗传衰老与暴露于绿色空间（绿色）有关；然而，纵向关系还没有得到很好的研究，特别是在少数群体中。我们研究了20年的绿化暴露[归一化植被指数（NDVI）]与表观遗传衰老之间的关系，研究对象是美国一个大型双种族（黑人/白人）城市队列。根据个人和社区社会经济特征调整的广义估计方程，绿化率越大，表观遗传衰老速度越慢。黑人受试者的周围绿度较低，绿度与表观遗传衰老之间的关联减弱[βNDVI5km:−0.80,95%可信区间（CI）：−4.75,3.13，白人受试者的βNDVI5km:−3.03,95% CI:−5.63,−0.43]。弱势社区的参与者表现出绿色与表观遗传衰老之间更强的关联（βNDVI5km:−3.36,95% CI:−6.65,−0.08，而弱势社区的βNDVI5km:−1.57,95% CI:−4.12,0.96）。总之，我们发现绿色与较慢的表观遗传衰老之间存在关系，并且与种族和社区社会经济地位等健康社会决定因素之间存在不同的关联。城市绿化与生物老化有关，绿化暴露的不平等可能导致健康老龄化的差异。
Slower epigenetic aging is associated with exposure to green space (greenness); however, the longitudinal relationship has not been well studied, particularly in minority groups. We investigated the association between 20-year exposure to greenness [Normalized Difference Vegetation Index (NDVI)] and epigenetic aging in a large, biracial (Black/white), U.S. urban cohort. Using generalized estimating equations adjusted for individual and neighborhood socioeconomic characteristics, greater greenness was associated with slower epigenetic aging. Black participants had less surrounding greenness and an attenuated association between greenness and epigenetic aging [βNDVI5km: −0.80, 95% confidence interval (CI): −4.75, 3.13 versus βNDVI5km: −3.03, 95% CI: −5.63, −0.43 in white participants]. Participants in disadvantaged neighborhoods showed a stronger association between greenness and epigenetic aging (βNDVI5km: −3.36, 95% CI: −6.65, −0.08 versus βNDVI5km: −1.57, 95% CI: −4.12, 0.96 in less disadvantaged). In conclusion, we found a relationship between greenness and slower epigenetic aging, and different associations by social determinants of health such as race and neighborhood socioeconomic status. Urban greenness is associated with biological aging, and inequality in greenness exposure may cause disparities in healthy aging.
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作者：
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影响因子：
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作者：
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通讯作者：
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DOI：
10.1093/gerona/glad026
发表时间：
2023-08-02
影响因子：
5.1
作者：
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