Mortality Associations With DNA Methylation-Based Biological Aging and Physical Functioning Measures Across a 20-Year Follow-up Period.
Mortality Associations With DNA Methylation-Based Biological Aging and Physical Functioning Measures Across a 20-Year Follow-up Period.
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DOI：
10.1093/gerona/glad026
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发表时间：
2023-08-02
影响因子：
5.1
通讯作者：
Sillanpaa, Elina
中科院分区：
文献类型：
--
作者：
Fohr, Tiina;Waller, Katja;Viljanen, Anne;Rantanen, Taina;Kaprio, Jaakko;Ollikainen, Miina;Sillanpaa, Elina
生物衰老的测量范围从基于DNA甲基化（DNAm）的估计到身体能力的测量。本研究的目的是比较基于DNAm和生理功能的生物衰老指标在预测死亡率方面的作用。我们研究了来自芬兰双胞胎衰老研究（FITSA）的63- 76岁女性（N = 395）。参与者的生物年龄（表观遗传时钟DNAm GrimAge和DunedinPACE）使用血液DNAm数据估计。在标准化实验室条件下进行的身体功能测试包括计时起身和行走（TUG）测试和10米步行测试。预测因子每增加1个标准差（SD）计算死亡风险比。对个体和双胞胎进行了Cox回归模型，后者控制潜在的遗传效应。这些模型根据已知的生活方式死亡率预测因素进行了调整。在随访期间（平均17.0年，0.2-20.3年），187名参与者死亡。在基于个体和两两分析中，GrimAge和衰老的两种功能性生物标志物与死亡率相关，与家庭关系、实足年龄、身体活动、体重指数、吸烟、教育或慢性疾病无关。在包括基于dna的测量和衰老的功能生物标志物的模型中，GrimAge和TUG仍然具有预测性。研究结果表明，DNAm GrimAge和TUG测试是独立于彼此和遗传影响的死亡率的有力预测指标。基于dna的测量和功能测试捕获了衰老过程的不同方面，因此作为预测死亡率的生物衰老测量相辅相成。
Measures of biological aging range from DNA methylation (DNAm)-based estimates to measures of physical abilities. The purpose of this study was to compare DNAm- and physical functioning-based measures of biological aging in predicting mortality. We studied 63- to 76-year-old women (N = 395) from the Finnish Twin Study on Aging (FITSA). Participants’ biological age (epigenetic clocks DNAm GrimAge and DunedinPACE) was estimated using blood DNAm data. Tests of physical functioning conducted under standardized laboratory conditions included the Timed Up and Go (TUG) test and 10-m walk test. Mortality hazard ratios were calculated per every 1 standard deviation (SD) increase in the predictor. Cox regression models were conducted for individuals and twin pairs, the latter controlling for underlying genetic effects. The models were adjusted for known lifestyle predictors of mortality. During the follow-up period (mean 17.0 years, range 0.2–20.3), 187 participants died. In both the individual-based and pairwise analyses, GrimAge and both functional biomarkers of aging were associated with mortality independent of family relatedness, chronological age, physical activity, body mass index, smoking, education, or chronic diseases. In a model including both the DNAm-based measures and functional biomarkers of aging, GrimAge and TUG remained predictive. The findings suggest that DNAm GrimAge and the TUG test are strong predictors of mortality independent of each others and genetic influences. DNAm-based measures and functional tests capture different aspects of the aging process and thus complement each other as measures of biological aging in predicting mortality.
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DOI：
10.1093/gerona/glab337
发表时间：
2022-09-01
影响因子：
5.1
作者：
Kankaanpaa, Anna;Tolvanen, Asko;Saikkonen, Pirkko;Heikkinen, Aino;Laakkonen, Eija K.;Kaprio, Jaakko;Ollikainen, Miina;Sillanpaa, Elina
通讯作者：
Sillanpaa, Elina
影响因子：
4.1
作者：
Ascencio EJ;Cieza-Gómez GD;Carrillo-Larco RM;Ortiz PJ
通讯作者：
Ortiz PJ
DOI：
10.1093/gerona/glt162
发表时间：
2014-06-01
影响因子：
5.1
作者：
Lowsky, David J.;Olshansky, S. Jay;Goldman, Dana P.
通讯作者：
Goldman, Dana P.
影响因子：
3.4
作者：
Idland, Gro;Engedal, Knut;Bergland, Astrid
通讯作者：
Bergland, Astrid
影响因子：
3
作者：
Christensen, G. T.;Osler, M.;Christensen, K.
通讯作者：
Christensen, K.