Individual and joint impact of family history and Helicobacter pylori infection on the risk of stomach cancer: a nested case-control study.
Individual and joint impact of family history and Helicobacter pylori infection on the risk of stomach cancer: a nested case-control study.
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DOI：
10.1038/sj.bjc.6602067
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发表时间：
2004-08-31
影响因子：
8.8
通讯作者：
中科院分区：
文献类型：
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作者：
我们使用日本癌症风险评估协作队列研究（JACC 研究）中的 202 例胃癌病例和 394 例对照来研究在控制幽门螺杆菌感染后，家族史是否对胃癌风险有独立影响。一名或多名一级亲属的胃癌阳性病史与女性患胃癌的风险增加有关，但在控制幽门螺杆菌感染和其他混杂变量后，男性则不然。与没有这些因素的女性相比，有家族史和幽门螺杆菌感染的女性患该病的风险增加五倍以上（OR 5.10，95% CI 1.58–16.5）。这些结果表明，女性对该疾病存在遗传易感性，并且对幽门螺杆菌感染的测量与家族史一起，可以对风险进行有意义的评估，而不仅仅是仅由任一因素提供的风险评估。
We used 202 cases of stomach cancer and 394 controls nested within the Japan Collaborative Cohort Study For Evaluation of Cancer Risk (JACC study) to investigate whether family history has an independent effect on the risk of stomach cancer after controlling for the Helicobacter pylori infection. A positive history of stomach cancer in one or more first-degree relatives was associated with an increased risk of the disease in women, but not in men after controlling for H. pylori infection and other confounding variables. Women with both a family history and H. pylori infection were associated with more than five-fold increased risk of the disease (OR 5.10, 95% CI 1.58–16.5) compared to those without these factors. These results suggest the existence of inherited susceptibility to the disease in women, and that measurements of H. pylori infection together with the family history allow meaningful evaluation of risk beyond that provided by either factor alone.
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DOI：
10.1111/j.1349-7006.1998.tb00504.x
发表时间：
1998-11-01
期刊：
JAPANESE JOURNAL OF CANCER RESEARCH
影响因子：
--
作者：
Kikuchi, S;Kurosawa, M;Sakiyama, T
通讯作者：
Sakiyama, T
影响因子：
6.4
作者：
Sasazuki, S;Sasaki, S;Tsugane, S
通讯作者：
Tsugane, S
影响因子：
8.4
作者：
Rocco, A;Staibano, S;Nardone, G
通讯作者：
Nardone, G
影响因子：
5.6
作者：
Toyoshima, H;Hayashi, S;Aoki, K
通讯作者：
Aoki, K
DOI：
10.1093/jnci/83.23.1734
发表时间：
1991-12-04
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
TALLEY, NJ;ZINSMEISTER, AR;BLASER, MJ
通讯作者：
BLASER, MJ