Long noncoding RNAs coordinate functions between mitochondria and the nucleus.
Long noncoding RNAs coordinate functions between mitochondria and the nucleus.
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长非编码RNA协调线粒体和细胞核之间的功能
DOI：
10.1186/s13072-017-0149-x
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发表时间：
2017-08-23
影响因子：
3.9
通讯作者：
Cui J
中科院分区：
文献类型：
--
作者：
Dong Y;Yoshitomi T;Hu JF;Cui J
在动物细胞中，线粒体是主要的发电站和代谢工厂。它们还含有基因组，可以产生特定的核酸和蛋白质。为了维持整个细胞的稳态，需要由编码的非编码RNA（ncRNA）以及蛋白质介导的线粒体和细胞核之间的强烈串扰。长ncRNA（lncRNA）含有特征性结构，并且它们参与基因表达的几乎每个阶段的调节，以及与多种疾病状态（例如癌症）有关。在协调信号系统中，在细胞核中转录但驻留在线粒体中的几种lncRNA在调节线粒体功能或动力学中起关键作用。例如，RMRP是线粒体RNase MRP的一种组分，对线粒体DNA复制和RNA加工很重要，类固醇受体RNA激活剂SRA是激素信号传导的关键调节剂，存在于细胞核和线粒体中。一些RNA结合蛋白可能在lncRNA转运系统中发挥作用，如HuR、GRSF 1、SHARP、SLIRP、PPR和PNPASE。此外，一系列的核DNA编码的lncRNA涉及的细胞凋亡，线粒体生物能量学和生物合成，和谷氨酰胺代谢。线粒体基因组也可以编码一组lncRNA，并且它们被分为三类：（1）lncND 5、lncND 6和lncCyt bRNA;（2）嵌合线粒体DNA编码的lncRNA;和（3）推定的线粒体DNA编码的lncRNA。据报道，线粒体DNA编码的lncRNA似乎在细胞核中起作用。在哺乳动物中，线粒体DNA编码的lncRNA向细胞核运输的分子机制现在才开始出现。总之，核和线粒体DNA编码的lncRNA介导了强烈的隔室间串扰，这为研究隔室间协调和维持全细胞稳态的机制开辟了丰富的领域。
In animal cells, mitochondria are the primary powerhouses and metabolic factories. They also contain genomes and can produce mitochondrial-specific nucleic acids and proteins. To maintain homeostasis of the entire cell, an intense cross-talk between mitochondria and the nucleus, mediated by encoded noncoding RNAs (ncRNAs), as well as proteins, is required. Long ncRNAs (lncRNAs) contain characteristic structures, and they are involved in the regulation of almost every stage of gene expression, as well as being implicated in a variety of disease states, such as cancer. In the coordinated signaling system, several lncRNAs, transcribed in the nucleus but residing in mitochondria, play a key role in regulating mitochondrial functions or dynamics. For example,RMRP, a component of the mitochondrial RNase MRP, is important for mitochondrial DNA replication and RNA processing, and the steroid receptor RNA activator,SRA, is a key modulator of hormone signaling and is present in both the nucleus and mitochondria. Some RNA-binding proteins maybe play a role in the lncRNAs transport system, such as HuR, GRSF1, SHARP, SLIRP, PPR, and PNPASE. Furthermore, a series of nuclear DNA-encoded lncRNAs were implicated in mitochondria-mediated apoptosis, mitochondrial bioenergetics and biosynthesis, and glutamine metabolism. The mitochondrial genome can also encode a set of lncRNAs, and they are divided into three categories: (1)lncND5,lncND6, andlncCyt bRNA; (2) chimeric mitochondrial DNA-encoded lncRNAs; and (3) putative mitochondrial DNA-encoded lncRNAs. It has been reported that the mitochondrial DNA-encoded lncRNAs appear to operate in the nucleus. The molecular mechanisms underlying trafficking of the mitochondrial DNA-encoded lncRNAs to the nucleus in mammals are only now beginning to emerge. In conclusion, both nuclear- and mitochondrial DNA-encoded lncRNAs mediate an intense intercompartmental cross-talk, which opens a rich field for investigation of the mechanism underlying the intercompartmental coordination and the maintenance of whole cell homeostasis.
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影响因子：
4
作者：
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通讯作者：
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影响因子：
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作者：
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DOI：
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发表时间：
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DOI：
10.1073/pnas.0903086106
发表时间：
2009-06-09
影响因子：
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