BDNF genotype and tDCS interaction in aphasia treatment.
BDNF genotype and tDCS interaction in aphasia treatment.
复制标题
DOI：
10.1016/j.brs.2018.08.009
复制
发表时间：
2018-11
影响因子：
7.7
通讯作者：
Bonilha L
中科院分区：
文献类型：
--
作者：
Fridriksson J;Elm J;Stark BC;Basilakos A;Rorden C;Sen S;George MS;Gottfried M;Bonilha L
几项研究，包括我们小组的随机对照试验，支持在行为失语症治疗期间将阳极tDCS（A-tDCS）应用于左半球以改善结局。解释A-tDCS功效的明确机制尚未建立，但可能涉及神经可塑性的调节。脑源性神经营养因子（BDNF）基因影响神经可塑性，并可能调节tDCS的作用。利用我们最近完成的试验数据，我们进行了一项有计划的测试，以确定失语症治疗结果是否受A-tDCS和BDNF基因rs6265单核苷酸多态性之间相互作用的影响。74例慢性卒中诱发性失语患者完成了15次语言治疗，并在每次治疗的前20分钟随机接受1 mA A-tDCS或假tDCS（S-tDCS）至完整的左颞顶区。BDNF基因型可用于67名参与者：37名参与者具有典型的瓦尔/瓦尔基因型。其余30名参与者具有非典型BDNF基因型（Met等位基因携带者）。主要结果因素是治疗完成后1周时物体命名的改善。在第4周和第24周评价治疗效果的维持。在治疗相关的命名改善方面，tDCS状况和基因型之间存在相互作用（F = 4.97，p = 0.03）。接受A-tDCS的瓦尔/瓦尔基因型参与者对失语症治疗的反应比接受S-tDCS的瓦尔/瓦尔参与者以及Met等位基因携带者更大，无论tDCS条件如何。具有瓦尔/瓦尔BDNF基因型的个体在失语症治疗期间更可能从A-tDCS中获益。
Several studies, including a randomized controlled trial by our group, support applying anodal tDCS (A-tDCS) to the left hemisphere during behavioral aphasia treatment to improve outcomes. A clear mechanism explaining A-tDCS’s efficacy has not been established, but modulation of neuroplasticity may be involved. The brain-derived neurotrophic factor (BDNF) gene influences neuroplasticity and may modulate the effects of tDCS. Utilizing data from our recently completed trial, we conducted a planned test of whether aphasia treatment outcome is influenced by interaction between A-tDCS and a single-nucleotide polymorphism of the BDNF gene, rs6265. Seventy-four individuals with chronic stroke-induced aphasia completed 15 language therapy sessions and were randomized to receive 1 mA A-tDCS or sham tDCS (S-tDCS) to the intact left temporoparietal region for the first 20 min of each session. BDNF genotype was available for 67 participants: 37 participants had the typical val/val genotype. The remaining 30 participants had atypical BDNF genotype (Met allele carriers). The primary outcome factor was improvement in object naming at 1 week after treatment completion. Maintenance of treatment effects was evaluated at 4 and 24 weeks. An interaction was revealed between tDCS condition and genotype for treatment-related naming improvement (F = 4.97, p = 0.03). Participants with val/val genotype who received A-tDCS showed greater response to aphasia treatment than val/val participants who received S-tDCS, as well as the Met allele carriers, regardless of tDCS condition. Individuals with the val/val BDNF genotype are more likely to benefit from A-tDCS during aphasia treatment.
登录
查看更多内容
影响因子：
2
作者：
Helm EE;Tyrell CM;Pohlig RT;Brady LD;Reisman DS
通讯作者：
Reisman DS
影响因子：
5.7
作者：
Fridriksson, Julius;Richardson, Jessica D.;Fillmore, Paul;Cai, Bo
通讯作者：
Cai, Bo
影响因子：
3.9
作者：
Lamb, Yvette N.;McKay, Nicole S.;Kirk, Ian J.
通讯作者：
Kirk, Ian J.
影响因子：
8.3
作者：
Fridriksson J;Richardson JD;Baker JM;Rorden C
通讯作者：
Rorden C
DOI：
10.1523/jneurosci.2227-10.2010
发表时间：
2010-09-01
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Fridriksson J
通讯作者：
Fridriksson J