Vanillin-bioglass cross-linked 3D porous chitosan scaffolds with strong osteopromotive and antibacterial abilities for bone tissue engineering.
Vanillin-bioglass cross-linked 3D porous chitosan scaffolds with strong osteopromotive and antibacterial abilities for bone tissue engineering.
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DOI：
10.1016/j.carbpol.2021.118440
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发表时间：
2021-11-01
影响因子：
11.2
通讯作者：
Sun H
中科院分区：
文献类型：
--
作者：
Hu J;Wang Z;Miszuk JM;Zhu M;Lansakara TI;Tivanski AV;Banas JA;Sun H
现有方法制备的壳聚糖交联支架不能满足骨组织工程应用的要求。我们开发了一种新的有效的交联技术，通过使用天然和安全的香草醛与明胶微粒一起产生抗菌，骨传导性和机械坚固的3D多孔壳聚糖-香草醛-明胶（CVB）支架。除了显著改善的机械性能之外，CVB支架具有高孔隙率（>90%）和互连的大孔结构。结果表明，壳聚糖的交联主要是由香草醛与壳聚糖的胺之间的Schiff碱反应以及它们之间形成的氢键和离子键引起的。重要的是，CVB支架不仅具有良好的生物相容性、生物活性和较强的抗菌能力，而且在体外显著促进成骨细胞分化、矿化和体内异位骨形成。因此，CVB支架具有强大的机械性能，骨传导性和抗菌能力，为骨组织工程应用带来了巨大的希望。
Chitosan scaffolds crosslinked by current methods insufficiently meet the demands of bone tissue engineering applications. We developed a novel effective crosslinking technique by using the natural and safe vanillin together with bioglass microparticles to generate an antibacterial, osteoconductive, and mechanically robust 3D porous chitosan-vanillin-bioglass (CVB) scaffold. In addition to the significantly improved mechanical properties, the CVB scaffolds had high porosity (>90%) and interconnected macroporous structures. Our data suggested that the crosslinking mainly resulted from the Schiff base reactions between the aldehydes of vanillin and amines of chitosan, together with the hydrogen and ionic bonds formed within them. Importantly, the CVB scaffolds not only showed good biocompatibility, bioactivity, and strong antibacterial ability but also significantly promoted osteoblastic differentiation, mineralization in vitro, and ectopic bone formation in vivo. Thus, the CVB scaffolds hold great promise for bone tissue engineering applications based on their robust mechanical properties, osteoconductivity, and antibacterial abilities.
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DOI：
10.3390/molecules19055898
发表时间：
2014-05-07
期刊：
Molecules (Basel, Switzerland)
影响因子：
--
作者：
Oliveira CB;Meurer YS;Oliveira MG;Medeiros WM;Silva FO;Brito AC;Pontes Dde L;Andrade-Neto VF
通讯作者：
Andrade-Neto VF
DOI：
10.1016/j.ijbiomac.2018.04.034
发表时间：
2018-08-01
影响因子：
8.2
作者：
Shariatinia, Zahra;Jalali, Azin Mazloom
通讯作者：
Jalali, Azin Mazloom
影响因子：
14
作者：
Murugan, R;Ramakrishna, S
通讯作者：
Ramakrishna, S
DOI：
10.2147/dddt.s165440
发表时间：
2018
期刊：
Drug design, development and therapy
影响因子：
--
作者：
Song R;Murphy M;Li C;Ting K;Soo C;Zheng Z
通讯作者：
Zheng Z
影响因子：
2.8
作者：
Peng, CH;Wang, YT;Cheng, G
通讯作者：
Cheng, G