Association of triglyceride-glucose index with ischemic stroke recurrence in nondiabetic patients with small vessel occlusion: a multicenter hospital-based prospective cohort study.
Association of triglyceride-glucose index with ischemic stroke recurrence in nondiabetic patients with small vessel occlusion: a multicenter hospital-based prospective cohort study.
复制标题
甘油三酯-葡萄糖指数与小血管闭塞非糖尿病患者缺血性卒中复发的关联：一项基于医院的多中心前瞻性队列研究
DOI：
10.1186/s12933-022-01693-4
复制
发表时间：
2022-11-17
影响因子：
9.3
通讯作者：
Jiang, Yongjun
中科院分区：
文献类型：
--
作者：
Wu, Li;Zhu, Jinmao;Li, Chenghao;Zhu, Juehua;Dai, Zheng;Jiang, Yongjun
关键词：
甘油三酯-葡萄糖（TyG）指数是一种简便、可靠的胰岛素抵抗替代指标。TyG指数升高与脑卒中复发有关。本研究旨在探讨TyG指数与非糖尿病小血管闭塞患者缺血性脑卒中复发的关系。筛选2016年11月1日至2021年2月28日发病后1周内连续入院的急性缺血性脑卒中患者。根据病史、实验室检查、心脏检查、血管检查和神经影像学检查确定脑卒中机制。纳入非糖尿病小血管闭塞患者，随访1年。主要终点为缺血性卒中复发。采用Logistic回归和Kaplan-Meier生存曲线分析TyG指数与脑卒中复发的关系。共筛选急性缺血性脑卒中患者6100例，其中纳入非糖尿病小血管闭塞患者1970例，根据TyG指数四分位数（Q1: < 8.20; Q2: 8.20 ~ 8.53; Q3: 8.54 ~ 8.92; Q4: > ~ 8.92）分为4组。4组患者在年龄、体重指数、收缩压、舒张压、降脂剂、梗死部位、空腹血糖、总胆固醇、甘油三酯、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、尿酸、卒中复发率等方面差异均有统计学意义。在多重调整模型中，与TyG指数Q1相比，TyG指数Q4与脑卒中复发的比值比为3.100（1.366-8.019）。TyG指数四分位数Kaplan-Meier生存（缺血性卒中无）曲线差异也有统计学意义（log-rank检验，P = 0.004）。我们的研究结果表明，TyG指数与非糖尿病小血管闭塞患者缺血性卒中复发相关，可以作为评估这些患者缺血性卒中复发风险的有价值的生物标志物。
Triglyceride-glucose (TyG) index is a simple and reliable surrogate marker of insulin resistance. Elevated TyG index was related to stroke recurrence. This study aimed to explore the associations between TyG index with ischemic stroke recurrence in nondiabetic patients with small vessel occlusion. From November 1, 2016 to February 28, 2021, consecutive acute ischemic stroke patients admitted within 1 week after onset were screened. The stroke mechanism was determined based on medical history, laboratory examinations, cardiac examinations, vascular examinations and neuroimaging. Nondiabetic patients with small vessel occlusion were enrolled and followed up for 1 year. The primary outcome was ischemic stroke recurrence. Logistic regression and Kaplan–Meier survival curve were used to analyze the association of the TyG index and stroke recurrence. A total of 6100 acute ischemic stroke patients were screened, with 1970 nondiabetic patients with small vessel occlusion included and divided into 4 groups according to the TyG index quartiles (Q1: < 8.20; Q2: 8.20–8.53; Q3: 8.54–8.92; Q4: > 8.92). There were significant differences in age, body mass index, systolic blood pression, diastolic blood pressure, lipid-lowering agents, infarct location, fasting blood glucose, total cholesterol, triglyceride, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, uric acid, and stroke recurrence among the 4 groups. In the multi-adjusted models, compared to Q1 of the TyG index, the odds ratio for Q4 of the TyG index for stroke recurrence was 3.100 (1.366–8.019). The Kaplan–Meier survival (ischemic stroke-free) curves by quartiles of the TyG index also showed statistically significant differences (log-rank test, P = 0.004). Our findings suggested that the TyG index was associated with ischemic stroke recurrence in nondiabetic patients with small vessel occlusion, and it could be a valuable biomarker for assessing the risk of ischemic stroke recurrence in these patients.
登录
查看更多内容
影响因子：
20.1
作者：
Mac Grory, Brian;Yaghi, Shadi;Cordonnier, Charlotte;Sposato, Luciano A.;Romano, Jose G.;Chaturvedi, Seemant
通讯作者：
Chaturvedi, Seemant
脑桥梗死复发的部位和机制：基于医院的随访研究
影响因子：
3.3
作者：
Wu, Li;Li, Youfu;Ye, Zeming;Liu, Dezhi;Dai, Zheng;Zhu, Juehua;Chen, Hongbing;Li, Chenghao;Lie, Chaowei;Jiang, Yongjun
通讯作者：
Jiang, Yongjun
缺血性脑卒中患者甘油三酯葡萄糖指数与颈总动脉内膜中层厚度
影响因子：
9.3
作者：
Miao M;Zhou G;Bao A;Sun Y;Du H;Song L;Cao Y;You S;Zhong C
通讯作者：
Zhong C
影响因子：
2.9
作者：
Hadwen J;Kim W;Dewar B;Ramsay T;Davis A;Dowlatshahi D;Shamy M
通讯作者：
Shamy M
影响因子：
3.4
作者：
Lin SF;Hu HH;Chao HL;Ho BL;Chen CH;Chan L;Lin HJ;Sun Y;Lin YY;Chen PL;Lin SK;Wei CY;Lin YT;Lee JT;Chao AC
通讯作者：
Chao AC