Iron-deficiency anemia in infancy and poorer cognitive inhibitory control at age 10 years.
Iron-deficiency anemia in infancy and poorer cognitive inhibitory control at age 10 years.
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DOI：
10.1111/dmcn.12118
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发表时间：
2013-05
影响因子：
3.8
通讯作者：
Lozoff B
中科院分区：
文献类型：
--
作者：
Algarín C;Nelson CA;Peirano P;Westerlund A;Reyes S;Lozoff B
The aim of this study was to assess the effects of iron-deficiency anemia (IDA) in infancy on executive functioning at age 10 years, specifically inhibitory control on the Go/No-Go task. We predicted that children who had IDA in infancy would show poorer inhibitory control. We assessed cognitive inhibitory control in 132 Chilean children (mean [SD] age 10y 0mo [1mo]): 69 children had IDA in infancy (45 males, 24 females) and 63 comparison children who did not have IDA (26 males, 37 females). Participants performed the Go/No-Go task with event-related potentials. Group differences in behavioral (accuracy, reaction time) and electrophysiological outcomes (N2 and P300 components) were analyzed using repeated-measures analyses of variance. N2 and P300 are interpreted to reflect attention and resource allocation respectively. Relative to comparison participants, children who had IDA in infancy showed slower reaction time (mean [SE], 528.7ms [14.2] vs 485.0ms [15.0], 95% confidence interval [CI] for difference between groups 0.9–86.5); lower accuracy (95.4% [0.5] vs 96.9% [0.6], 95% CI −3.0 to −0.1); longer latency to N2 peak (378.9ms [4.9] vs 356.9ms [5.0], 95% CI 7.5–36.6); and smaller P300 amplitude (4.5μV [0.8] vs 7.6μV [0.9], 95% CI–5.5 to −0.5). IDA in infancy was associated with slower reaction times and poorer inhibitory control 8 to 9 years after iron therapy. These findings are consistent with the long-lasting effects of early IDA on myelination and/or prefrontal–striatal circuits where dopamine is the major neurotransmitter.
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影响因子：
1.3
作者：
Falkenstein, M;Hoormann, J;Hohnsbein, J
通讯作者：
Hohnsbein, J
影响因子：
2.9
作者：
Nieuwenhuis, Sander;Yeung, Nick;Ridderinkhof, K. Richard
通讯作者：
Ridderinkhof, K. Richard
影响因子：
11.3
作者：
Antolin, Tim;Berman, Steven M.;Noble, Ernest P.
通讯作者：
Noble, Ernest P.
影响因子：
4.7
作者：
Bokura, H;Yamaguchi, S;Kobayashi, S
通讯作者：
Kobayashi, S
影响因子：
1.9
作者：
Lozoff, Betsy
通讯作者：
Lozoff, Betsy