Integrins and their potential roles in mammalian pregnancy.
Integrins and their potential roles in mammalian pregnancy.
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整合素及其在哺乳动物妊娠中的潜在作用。
DOI：
10.1186/s40104-023-00918-0
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发表时间：
2023-09-08
影响因子：
7
通讯作者：
Cain, Joe W.
中科院分区：
文献类型：
--
作者：
Johnson, Gregory A.;Burghardt, Robert C.;Bazer, Fuller W.;Seo, Heewon;Cain, Joe W.
整合素是一个高度复杂的受体家族，当在细胞表面上表达时，其可以介导相互的细胞与细胞和细胞与细胞外基质（ECM）相互作用，导致整合素粘附复合物（IAC）的组装，所述整合素粘附复合物在膜处和细胞质内更深处启动许多信号传导功能以协调包括细胞粘附、迁移、增殖、存活、分化和代谢的过程。所有多细胞动物生物都具有整合素，人们普遍认为整合素与多细胞的进化有关，对于胚胎发育期间细胞与邻近细胞和周围环境的结合以及细胞和分子生物学的许多方面至关重要。整联蛋白在胚胎发育、正常生理学和疾病过程的许多方面具有重要作用，发现并阐明了整联蛋白的多种功能，其直接影响生物学和医学的许多领域，包括哺乳动物妊娠，特别是胚泡植入子宫壁，随后的胎盘形成和孕体（胚胎/胎儿和相关的胎盘膜）发育。这篇综述提供了一个简洁的概述整合素的结构，配体结合，和信号随后的胚胎发育，植入和早期胎盘在猪，羊，人类和小鼠作为啮齿动物的例子简明扼要的概述。整合素亚单位的子宫腔上皮（LE）和孕体滋养层的初始定位的一个简短的时间轴，然后由猪，绵羊，人类和啮齿动物妊娠期间的整合素表达和功能的顺序总结。作为适当的这本杂志，整合素的表达和功能在猪和羊妊娠期间的总结是深入的，而人类和啮齿动物的总结是简短的。由于与图1、2、3、4、5和6中所示的模型类似的模型在整个科学文献中存在，因此出于娱乐目的，本手稿中的插图被起草为维京海盗图像。
Integrins are a highly complex family of receptors that, when expressed on the surface of cells, can mediate reciprocal cell-to-cell and cell-to-extracellular matrix (ECM) interactions leading to assembly of integrin adhesion complexes (IACs) that initiate many signaling functions both at the membrane and deeper within the cytoplasm to coordinate processes including cell adhesion, migration, proliferation, survival, differentiation, and metabolism. All metazoan organisms possess integrins, and it is generally agreed that integrins were associated with the evolution of multicellularity, being essential for the association of cells with their neighbors and surroundings, during embryonic development and many aspects of cellular and molecular biology. Integrins have important roles in many aspects of embryonic development, normal physiology, and disease processes with a multitude of functions discovered and elucidated for integrins that directly influence many areas of biology and medicine, including mammalian pregnancy, in particular implantation of the blastocyst to the uterine wall, subsequent placentation and conceptus (embryo/fetus and associated placental membranes) development. This review provides a succinct overview of integrin structure, ligand binding, and signaling followed with a concise overview of embryonic development, implantation, and early placentation in pigs, sheep, humans, and mice as an example for rodents. A brief timeline of the initial localization of integrin subunits to the uterine luminal epithelium (LE) and conceptus trophoblast is then presented, followed by sequential summaries of integrin expression and function during gestation in pigs, sheep, humans, and rodents. As appropriate for this journal, summaries of integrin expression and function during gestation in pigs and sheep are in depth, whereas summaries for humans and rodents are brief. Because similar models to those illustrated in Fig. 1, 2, 3, 4, 5 and 6 are present throughout the scientific literature, the illustrations in this manuscript are drafted as Viking imagery for entertainment purposes.
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