Oxytocin, vasopressin and estrogen receptor gene expression in relation to social recognition in female mice.
Oxytocin, vasopressin and estrogen receptor gene expression in relation to social recognition in female mice.
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DOI：
10.1016/j.physbeh.2011.10.025
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发表时间：
2012-02-28
影响因子：
2.9
通讯作者：
Choleris E
中科院分区：
文献类型：
--
作者：
Clipperton-Allen AE;Lee AW;Reyes A;Devidze N;Phan A;Pfaff DW;Choleris E
物种间和物种内与社会行为和识别相关的激素和受体的差异表明，不同的分布和/或表达模式可能与社会识别有关。用定量逆转录聚合酶链式反应研究发情前期雌性小鼠雌激素受体-α(ER-α)、雌激素受体-β(ER-β)、孕激素受体(PR)、催产素(OT)及其受体、加压素及其受体表达的自然差异。在暴露于相同的两种同种物质的4次5分钟后，在最后的试验(T5)中，其中一只被一只新的小鼠取代。在8个与社会相关的大脑区域中，检测了表现出高(85-100%)和低(40-60%)社会认知分数(即，在T5优先进行新的小鼠研究)的小鼠的基因表达。结果支持OT和AVP参与社会再认，提示在内侧视前区，OT和AVP mRNA的增加以及ERα和ERβ基因的激活与社会再认的改善有关。最初的社会调查与背外侧隔区的ER、PR和OTR相关，提示这些受体可能在不影响社会认知的情况下调节社会兴趣。最后，LR小鼠杏仁核外侧核基因的激活增加可能与一般学习障碍有关，而杏仁核外侧核活动的减少可能表明HR小鼠的认知机制更有效。
Inter- and intra-species differences in social behavior and recognition-related hormones and receptors suggest that different distribution and/or expression patterns may relate to social recognition. We used qRT-PCR to investigate naturally occurring differences in expression of estrogen receptor-alpha (ERα), ER-beta (ERβ), progesterone receptor (PR), oxytocin (OT) and receptor, and vasopressin (AVP) and receptors in proestrous female mice. Following four 5 min exposures to the same two conspecifics, one was replaced with a novel mouse in the final trial (T5). Gene expression was examined in mice showing high (85–100%) and low (40–60%) social recognition scores (i.e., preferential novel mouse investigation in T5) in eight socially-relevant brain regions. Results supported OT and AVP involvement in social recognition, and suggest that in the medial preoptic area, increased OT and AVP mRNA, together with ERα and ERβ gene activation, relate to improved social recognition. Initial social investigation correlated with ERs, PR and OTR in the dorsolateral septum, suggesting that these receptors may modulate social interest without affecting social recognition. Finally, increased lateral amygdala gene activation in the LR mice may be associated with general learning impairments, while decreased lateral amygdala activity may indicate more efficient cognitive mechanisms in the HR mice.
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影响因子：
64.8
作者：
Amdam, GV;Csondes, A;Page, RE
通讯作者：
Page, RE
DOI：
10.1073/pnas.0807412105
发表时间：
2008-11-04
影响因子：
11.1
作者：
Bosch, Oliver J.;Neumann, Inga D.
通讯作者：
Neumann, Inga D.
影响因子：
16.2
作者：
Bielsky, IF;Hu, SB;Young, LJ
通讯作者：
Young, LJ
影响因子：
2.9
作者：
DuboisDauphin, M;Barberis, C;deBilbao, F
通讯作者：
deBilbao, F
影响因子：
3.2
作者：
Bosch, O. J.;Pfoertsch, J.;Neumann, I. D.
通讯作者：
Neumann, I. D.