The medial septum controls hippocampal supra-theta oscillations.
The medial septum controls hippocampal supra-theta oscillations.
复制标题
DOI：
10.1038/s41467-023-41746-0
复制
发表时间：
2023-10-10
影响因子：
16.6
通讯作者：
Hangya, Balazs
中科院分区：
文献类型：
--
作者：
Kiraly, Balint;Domonkos, Andor;Jelitai, Marta;Lopes-dos-Santos, Vitor;Martinez-Bellver, Sergio;Kocsis, Barnabas;Schlingloff, Daniel;Joshi, Abhilasha;Salib, Minas;Fiath, Richard;Bartho, Peter;Ulbert, Istvan;Freund, Tamas F.;Viney, Tim J.;Dupret, David;Varga, Viktor;Hangya, Balazs
Hippocampal theta oscillations orchestrate faster beta-to-gamma oscillations facilitating the segmentation of neural representations during navigation and episodic memory. Supra-theta rhythms of hippocampal CA1 are coordinated by local interactions as well as inputs from the entorhinal cortex (EC) and CA3 inputs. However, theta-nested gamma-band activity in the medial septum (MS) suggests that the MS may control supra-theta CA1 oscillations. To address this, we performed multi-electrode recordings of MS and CA1 activity in rodents and found that MS neuron firing showed strong phase-coupling to theta-nested supra-theta episodes and predicted changes in CA1 beta-to-gamma oscillations on a cycle-by-cycle basis. Unique coupling patterns of anatomically defined MS cell types suggested that indirect MS-to-CA1 pathways via the EC and CA3 mediate distinct CA1 gamma-band oscillations. Optogenetic activation of MS parvalbumin-expressing neurons elicited theta-nested beta-to-gamma oscillations in CA1. Thus, the MS orchestrates hippocampal network activity at multiple temporal scales to mediate memory encoding and retrieval. Timing is key for efficient coding and communication across brain areas. Here, the authors found that the medial septum orchestrates hippocampal network activity at multiple temporal scales likely mediating memory encoding and retrieval.
登录
查看更多内容
影响因子：
2.5
作者：
Apartis, E;Poindessous-Jazat, FR;Bassant, MH
通讯作者：
Bassant, MH
影响因子：
3.7
作者：
Broncel A;Bocian R;Kłos-Wojtczak P;Konopacki J
通讯作者：
Konopacki J
影响因子：
64.8
作者：
COBB, SR;BUHL, EH;SOMOGYI, P
通讯作者：
SOMOGYI, P
影响因子：
25
作者：
Brandon, Mark P.;Bogaard, Andrew R.;Hasselmo, Michael E.
通讯作者：
Hasselmo, Michael E.
DOI：
10.1523/jneurosci.4122-11.2012
发表时间：
2012-01-11
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Belluscio MA;Mizuseki K;Schmidt R;Kempter R;Buzsáki G
通讯作者：
Buzsáki G