Prevalence of human herpesvirus 8 and hepatitis C virus in a rural community with a high risk for blood-borne infections in central China.
Prevalence of human herpesvirus 8 and hepatitis C virus in a rural community with a high risk for blood-borne infections in central China.
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DOI：
10.1111/j.1469-0691.2010.03287.x
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发表时间：
2011-03
期刊：
影响因子：
--
通讯作者：
Wood C
中科院分区：
文献类型：
--
作者：
Zhang T;He N;Ding Y;Crabtree K;Minhas V;Wood C
在过去的十年里，非法献血已经在中国的一些农村地区造成了艾滋病疫情。其他与艾滋病毒相关的病毒感染，如人类疱疹病毒8（HHV 8）在这些地区仍然没有得到很好的界定。为了解山西省某县非法采血人群中HHV 8和HCV感染情况及可能的危险因素，对山西省某县305名HIV阳性和315名HIV阴性人群进行了横断面调查。对这些参与者进行了访谈问卷和血清检测。HIV阳性组HCV和HHV 8阳性率分别为76.4%和15.4%，高于HIV阴性组的2.5%和4.8%，而HBV阳性率差异无统计学意义。HCV和HHV 8的合并感染在HIV阳性组中也更普遍。HIV状态（比值比[OR]，2.71; 95%可信区间[CI]，1.16-6.30）和HBV状态（OR，2.56; 95%CI：1.14-5.75）与HHV 8感染独立相关。HIV感染状况（OR，23.03; 95%CI：9.95-53.27）和卖血/卖血浆史（OR，14.57; 95%CI：7.49-28.23）与HCV感染密切相关。这些发现表明，HHV 8和HCV感染在该社区普遍存在。HIV感染是HHV 8和HCV感染的重要危险因素。HBV感染与HHV 8感染有关，但与HCV感染无关。HHV 8和HBV可能在该人群中具有相似的传播方式，而HCV可能没有。
Former illegal blood donation in the past decade has caused HIV outbreaks in some rural areas in China. Other HIV associated virus infections, such as human herpesvirus 8 (HHV8) in such areas are still not well defined. In order to explore HHV8 and HCV seroprevalence and potential risk factors in such areas, a cross-sectional study with 305 HIV positive and 315 HIV negative subjects recruited from a rural county in Shanxi province was conducted, where illegal blood collection was reported. Interview questionnaires and serum testing were carried out with these participants. HCV and HHV8 seroprevalence were found to be higher in HIV positive than negative group (76.4% vs. 2.5%; 15.4% vs. 4.8% respectively), while the difference in HBV seroprevalence was not significant. Co-infection with HCV and HHV8 was also more prevalent in the HIV positive group. HIV status (odds ratio [OR], 2.71; 95% confidence interval [CI], 1.16–6.30) and HBV status (OR, 2.56; 95%CI: 1.14–5.75) were independently associated with HHV8 infection. HIV status (OR, 23.03; 95%CI: 9.95–53.27) and blood/plasma selling history (OR, 14.57; 95%CI: 7.49–28.23) were strongly associated with HCV infection. These findings demonstrate that both HHV8 and HCV infections are prevalent in this community. HIV infection is an important risk factor for both HHV8 and HCV infection. HBV infection is associated with HHV8 infection but not with HCV infection. It is possible that HHV8 and HBV, but not HCV, may have similar mode of transmission in this population.
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