Homeostatic regulation of the endoneurial microenvironment during development, aging and in response to trauma, disease and toxic insult.
Homeostatic regulation of the endoneurial microenvironment during development, aging and in response to trauma, disease and toxic insult.
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DOI：
10.1007/s00401-010-0783-x
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发表时间：
2011-03
影响因子：
12.7
通讯作者：
Weerasuriya A
中科院分区：
文献类型：
--
作者：
Mizisin AP;Weerasuriya A
神经内膜微环境由神经内膜血管的内皮和多层神经鞘膜界定，是轴突、相关的雪旺细胞和周围神经的其他驻留细胞在其中发挥功能的特化内环境。内皮和神经束膜限制并调节神经内膜微环境和周围细胞外空间之间的物质交换，因此更适合描述为血神经界面（BNI）而不是血神经屏障（BNB）。神经内膜微环境的输入和输出通过血液-神经交换和由近端-远端静水压力梯度驱动的对流神经内膜流体流动发生。在发育、衰老和创伤反应过程中，BNI的内皮和神经束膜成分的独立调节与神经内膜微环境的稳态调节一致。实验性变态反应性神经炎（EAN）、糖尿病和铅性神经病中神经内膜的病理生理学改变被认为是神经内膜稳态的扰动。许旺细胞、轴突、巨噬细胞和肥大细胞通过细胞-细胞和细胞-基质信号传导的相互作用调节该界面的渗透性。更好地了解紧密连接的动态性质以及诱导和/或调节BNI的这些关键要素的因素将增加我们对周围神经疾病的理解，并刺激治疗这些疾病的治疗策略的发展。
The endoneurial microenvironment, delimited by the endothelium of endoneurial vessels and a multi-layered ensheathing perineurium, is a specialized milieu intérieur within which axons, associated Schwann cells and other resident cells of peripheral nerves function. The endothelium and perineurium restricts as well as regulates exchange of material between the endoneurial microenvironment and the surrounding extracellular space and thus is more appropriately described as a blood–nerve interface (BNI) rather than a blood–nerve barrier (BNB). Input to and output from the endoneurial microenvironment occurs via blood–nerve exchange and convective endoneurial fluid flow driven by a proximo-distal hydrostatic pressure gradient. The independent regulation of the endothelial and perineurial components of the BNI during development, aging and in response to trauma is consistent with homeostatic regulation of the endoneurial microenvironment. Pathophysiological alterations of the endoneurium in experimental allergic neuritis (EAN), and diabetic and lead neuropathy are considered to be perturbations of endoneurial homeostasis. The interactions of Schwann cells, axons, macrophages, and mast cells via cell–cell and cell–matrix signaling regulate the permeability of this interface. A greater knowledge of the dynamic nature of tight junctions and the factors that induce and/or modulate these key elements of the BNI will increase our understanding of peripheral nerve disorders as well as stimulate the development of therapeutic strategies to treat these disorders.
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影响因子：
3.1
作者：
BUNDGAARD, M;FROKJAERJENSEN, J
通讯作者：
FROKJAERJENSEN, J
影响因子：
8.2
作者：
Eaton, RP;Qualls, C;Griffey, RH
通讯作者：
Griffey, RH
影响因子：
14.5
作者：
BROWN, WF;FEASBY, TE
通讯作者：
FEASBY, TE
影响因子：
--
作者：
BURKEL, WE
通讯作者：
BURKEL, WE
DOI：
10.1007/bf00368249
发表时间：
1965-01-01
期刊：
ZEITSCHRIFT FUR ZELLFORSCHUNG UND MIKROSKOPISCHE ANATOMIE
影响因子：
--
作者：
ENERBACK, L;OLSSON, Y;SOURANDER, P
通讯作者：
SOURANDER, P