Antibody Responses to SARS-CoV-2 Antigens in Humans and Animals.
Antibody Responses to SARS-CoV-2 Antigens in Humans and Animals.
复制标题
人和动物对SARS-CoV-2抗原的抗体应答
DOI：
10.3390/vaccines8040684
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发表时间：
2020-11-16
期刊：
影响因子：
7.8
通讯作者：
Webby RJ
中科院分区：
文献类型：
--
作者：
Kim H;Seiler P;Jones JC;Ridout G;Camp KP;Fabrizio TP;Jeevan T;Miller LA;Throm RE;Ferrara F;Fredrickson RL;Lowe JF;Wang L;Odemuyiwa SO;Wan XF;Webby RJ
为了优化2019冠状病毒病（COVID-19）的公共卫生应对措施，我们必须首先了解抗体对严重急性呼吸道综合征相关冠状病毒2（SARS-CoV-2）上单个蛋白质的反应，以及抗体对其他冠状病毒的交叉反应性。使用一组37份恢复期COVID-19人类血清样本，我们发现反应的幅度和特异性在个体之间存在差异，与他们对季节性人类冠状病毒（HCoV）的反应无关。这些数据表明，COVID-19疫苗将在未经感染的个体中引发原发性体液免疫应答，并在先前暴露于SARS-CoV-2的个体中引发可变应答。与人类有限的交叉冠状病毒反应不同，96只狗和10只猫的血清样本显示SARS-CoV-2蛋白特异性反应集中在非S1蛋白上。这种反应与对其他冠状病毒的反应的相关性表明，这些抗体是交叉反应性的，并在这些宿主中产生地方性病毒，这在血清流行病学研究中必须考虑。我们的结论是，针对冠状病毒蛋白的抗体产生的实质性变化将影响临床和兽医环境中血清学数据的解释。
To optimize the public health response to coronavirus disease 2019 (COVID-19), we must first understand the antibody response to individual proteins on the severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) and the antibody’s cross reactivity to other coronaviruses. Using a panel of 37 convalescent COVID-19 human serum samples, we showed that the magnitude and specificity of responses varied across individuals, independent of their reactivity to seasonal human coronaviruses (HCoVs). These data suggest that COVID-19 vaccines will elicit primary humoral immune responses in naïve individuals and variable responses in those previously exposed to SARS-CoV-2. Unlike the limited cross-coronavirus reactivities in humans, serum samples from 96 dogs and 10 cats showed SARS-CoV-2 protein-specific responses focused on non–S1 proteins. The correlation of this response with those to other coronaviruses suggests that the antibodies are cross-reactive and generated to endemic viruses within these hosts, which must be considered in seroepidemiologic studies. We conclude that substantial variation in antibody generation against coronavirus proteins will influence interpretations of serologic data in the clinical and veterinary settings.
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影响因子：
11.8
作者：
Brown, Meredith A.;Troyer, Jennifer L.;O'Brien, Stephen J.
通讯作者：
O'Brien, Stephen J.
影响因子：
82.9
作者：
Long, Quan-Xin;Liu, Bai-Zhong;Huang, Ai-Long
通讯作者：
Huang, Ai-Long
影响因子：
24.8
作者：
Isho B;Abe KT;Zuo M;Jamal AJ;Rathod B;Wang JH;Li Z;Chao G;Rojas OL;Bang YM;Pu A;Christie-Holmes N;Gervais C;Ceccarelli D;Samavarchi-Tehrani P;Guvenc F;Budylowski P;Li A;Paterson A;Yue FY;Marin LM;Caldwell L;Wrana JL;Colwill K;Sicheri F;Mubareka S;Gray-Owen SD;Drews SJ;Siqueira WL;Barrios-Rodiles M;Ostrowski M;Rini JM;Durocher Y;McGeer AJ;Gommerman JL;Gingras AC
通讯作者：
Gingras AC
DOI：
10.1073/pnas.2010817117
发表时间：
2020-10-06
影响因子：
11.1
作者：
Segalés J;Puig M;Rodon J;Avila-Nieto C;Carrillo J;Cantero G;Terrón MT;Cruz S;Parera M;Noguera-Julián M;Izquierdo-Useros N;Guallar V;Vidal E;Valencia A;Blanco I;Blanco J;Clotet B;Vergara-Alert J
通讯作者：
Vergara-Alert J
影响因子：
64.8
作者：
Arvin, Ann M.;Fink, Katja;Virgin, Herbert W.
通讯作者：
Virgin, Herbert W.