Isotypes of Epstein-Barr virus antibodies in rheumatoid arthritis: association with rheumatoid factors and citrulline-dependent antibodies.
Isotypes of Epstein-Barr virus antibodies in rheumatoid arthritis: association with rheumatoid factors and citrulline-dependent antibodies.
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DOI：
10.1155/2015/472174
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发表时间：
2015
影响因子：
--
通讯作者：
Houen G
中科院分区：
文献类型：
--
作者：
Westergaard MW;Draborg AH;Troelsen L;Jacobsen S;Houen G
为研究类风湿关节炎（RA）患者抗EB病毒（EBV）的体液免疫应答，并与RA的两种主要自身抗体进行比较，采用酶联免疫吸附试验（ELISA）检测了77例RA患者、28例系统性红斑狼疮（SLE）患者和28例健康对照者的血浆标本。与SLE患者和HC相比，RA患者中针对潜伏性EBV核抗原-1（EBNA-1）的IgG/伊加/IgM抗体阳性百分比和浓度增加。增加的浓度和百分比的IgG/伊加/IgM阳性对早期溶解性EBV抗原弥漫性（EAD）也发现在RA患者相比，HC，但最高的SLE患者。此外，EBNA-1伊加和EBNA-1 IgM水平升高与IgM和伊加类风湿因子（RF）和抗瓜氨酸化蛋白抗体的存在之间的关系，ACPA，IgG）之间以及RA患者中针对EAD的伊加浓度升高与RF和ACPA的存在之间的关系。因此，RA患者的潜伏性EBV感染的所有同种型特征抗体升高（而SLE患者的溶解性EBV感染的抗体升高）。值得注意的是，对于IgM和伊加（而不是IgG），这些与特征性RA自身抗体的存在有关。
In order to study the humoral immune response against Epstein-Barr virus (EBV) in patients with rheumatoid arthritis (RA) and to compare it with the two major autoantibody types in RA, plasma samples from 77 RA patients, 28 patients with systemic lupus erythematosus (SLE), and 28 healthy controls (HCs) were investigated by enzyme-linked immunosorbent assays (ELISA). Increased percentages of positives and concentrations of IgG/IgA/IgM antibodies against the latent EBV nuclear antigen-1 (EBNA-1) were observed in RA patients compared to SLE patients and HCs. Increased concentrations and percentages of positives of IgG/IgA/IgM against the early lytic EBV antigen diffuse (EAD) were also found in RA patients compared to HCs but were highest in SLE patients. Furthermore, associations between the elevated EBNA-1 IgA and EBNA-1 IgM levels and the presence of IgM and IgA rheumatoid factors (RFs) and anti-citrullinated protein antibodies (ACPAs, IgG) and between elevated IgA concentrations against EAD and the presence of RFs and ACPAs in RA patients were found. Thus, RA patients had elevated antibodies of all isotypes characteristic of latent EBV infection (whereas SLE patients had elevated antibodies characteristic of lytic EBV infection). Notably, for IgM and IgA (but not IgG), these were associated with the presence of characteristic RA autoantibodies.
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影响因子：
4.9
作者：
Matsuo, Kosuke;Xiang, Yang;Nakamura, Hiroshi;Masuko, Kayo;Yudoh, Kazuo;Noyori, Koji;Nishioka, Kusuki;Saito, Tomoyuki;Kato, Tomohiro
通讯作者：
Kato, Tomohiro
影响因子：
2.1
作者：
Draborg, A. H.;Jorgensen, J. M.;Duus, K.
通讯作者：
Duus, K.
影响因子：
15.9
作者：
FERRELL, PB;AITCHESON, CT;TAN, EM
通讯作者：
TAN, EM
影响因子：
2.1
作者：
MCDERMOTT, M;MOLLOY, M;GREALLY, J
通讯作者：
GREALLY, J
影响因子：
15.9
作者：
ALSPAUGH, MA;HENLE, G;HENLE, W
通讯作者：
HENLE, W