Single units in the medial prefrontal cortex with anxiety-related firing patterns are preferentially influenced by ventral hippocampal activity.
Single units in the medial prefrontal cortex with anxiety-related firing patterns are preferentially influenced by ventral hippocampal activity.
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DOI：
10.1016/j.neuron.2011.07.027
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发表时间：
2011-09-08
期刊：
影响因子：
16.2
通讯作者：
Gordon JA
中科院分区：
文献类型：
--
作者：
Adhikari A;Topiwala MA;Gordon JA
内侧前额叶皮质(MPFC)和腹侧海马区(VHPC)在先天焦虑任务中相互作用。为了探索这种相互作用的后果，我们检查了与任务相关的单个单位的激发，这些单位来自探索标准版本和改进版本的高架加迷宫(EPM)的小鼠的mPFC，EPM是一种天生的焦虑范式。同时监测海马局灶场电位(LFP)。MPFC单位的数量在迷宫中区分安全和厌恶的位置，与引起焦虑的刺激的性质无关。值得注意的是，任务相关活动较强的mPFC单位与vHPC LFP中的theta频率活动耦合更强。最后，与任务相关的活动与焦虑的行为指标呈负相关。这些结果阐明了vHPC-mPFC回路在先天性焦虑中的作用，并强调了特定的输入如何参与mPFC内与行为相关的神经活动的产生。
The medial prefrontal cortex (mPFC) and ventral hippocampus (vHPC) functionally interact during innate anxiety tasks. To explore the consequences of this interaction, we examined task-related firing of single units from the mPFC of mice exploring standard and modified versions of the elevated plus maze (EPM), an innate anxiety paradigm. Hippocampal local field potentials (LFPs) were simultaneously monitored. The population of mPFC units distinguished between safe and aversive locations within the maze, regardless of the nature of the anxiogenic stimulus. Strikingly, mPFC units with stronger task-related activity were more strongly coupled to theta-frequency activity in the vHPC LFP. Lastly, task-related activity was inversely correlated with behavioral measures of anxiety. These results clarify the role of the vHPC-mPFC circuit in innate anxiety, and underscore how specific inputs may be involved in the generation of behaviorally relevant neural activity within the mPFC.
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影响因子：
2.7
作者：
Burton, Brian G.;Hok, Vincent;Poucet, Bruno
通讯作者：
Poucet, Bruno
影响因子：
2.9
作者：
Gonzalez, LE;Rujano, M;Hernandez, L
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影响因子：
3.6
作者：
Hogg, S
通讯作者：
Hogg, S
DOI：
10.1073/pnas.0404965101
发表时间：
2004-09-07
影响因子：
11.1
作者：
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通讯作者：
Balsam, P
影响因子：
25
作者：
Fujisawa, Shigeyoshi;Amarasingham, Asohan;Buzsaki, Gyoergy
通讯作者：
Buzsaki, Gyoergy